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Animal rabies control has been frustrated by the existence of multiple wildlife reservoirs and the lack of efficacious oral vaccines. In this investigation, raccoons fed a vaccinia-rabies glycoprotein recombinant virus in a sponge bait developed rabies virus-neutralizing antibody (0.6-54.0 units) and resisted street rabies virus infection 28 and 205 days after feeding. Additional raccoons immunized by oral infusion with attenuated antigenic variants of rabies virus strains CVS-11 and ERA failed to develop rabies virus-neutralizing antibody. This work demonstrates the feasibility of a recombinant virus vaccine containing the rabies glycoprotein gene for immunization of raccoons, and possibly other wildlife, to obtain long-term protection against rabies.
C E Rupprecht, and
T J Wiktor, and
D H Johnston, and
A N Hamir, and
B Dietzschold, and
W H Wunner, and
L T Glickman, and
H Koprowski
January 1988,
Reviews of infectious diseases,
C E Rupprecht, and
T J Wiktor, and
D H Johnston, and
A N Hamir, and
B Dietzschold, and
W H Wunner, and
L T Glickman, and
H Koprowski
March 1989,
American journal of veterinary research,
C E Rupprecht, and
T J Wiktor, and
D H Johnston, and
A N Hamir, and
B Dietzschold, and
W H Wunner, and
L T Glickman, and
H Koprowski
October 1989,
Journal of wildlife diseases,
C E Rupprecht, and
T J Wiktor, and
D H Johnston, and
A N Hamir, and
B Dietzschold, and
W H Wunner, and
L T Glickman, and
H Koprowski
January 1992,
Journal of wildlife diseases,
C E Rupprecht, and
T J Wiktor, and
D H Johnston, and
A N Hamir, and
B Dietzschold, and
W H Wunner, and
L T Glickman, and
H Koprowski
October 2007,
Vaccine,
C E Rupprecht, and
T J Wiktor, and
D H Johnston, and
A N Hamir, and
B Dietzschold, and
W H Wunner, and
L T Glickman, and
H Koprowski
July 2018,
Journal of wildlife diseases,
C E Rupprecht, and
T J Wiktor, and
D H Johnston, and
A N Hamir, and
B Dietzschold, and
W H Wunner, and
L T Glickman, and
H Koprowski
October 2012,
Journal of wildlife diseases,
C E Rupprecht, and
T J Wiktor, and
D H Johnston, and
A N Hamir, and
B Dietzschold, and
W H Wunner, and
L T Glickman, and
H Koprowski
July 1985,
Journal of wildlife diseases,
C E Rupprecht, and
T J Wiktor, and
D H Johnston, and
A N Hamir, and
B Dietzschold, and
W H Wunner, and
L T Glickman, and
H Koprowski
April 2019,
Journal of wildlife diseases,
C E Rupprecht, and
T J Wiktor, and
D H Johnston, and
A N Hamir, and
B Dietzschold, and
W H Wunner, and
L T Glickman, and
H Koprowski
April 1990,
Journal of wildlife diseases,
