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Prostaglandins may be implicated in the bronchoconstriction which occurs in asthma. Prostaglandins F2 alpha (PGF2 alpha) and D2 (PGD2) have been reported to produce bronchoconstriction in asthmatic subjects in vivo and PGF2 alpha contracts human isolated airway smooth muscle. We examined the relative efficacy and potency of PGF2 alpha and PGD2 on human bronchial spiral strips taken from 6 patients at thoracotomy. PGF2 alpha had greater efficacy than PGD2. The mean % Tmax (percentage of maximal contractile response) +/- s.e. mean were 84 +/- 7 and 54 +/- 7 respectively (P less than 0.05). PGF2 alpha (mean pD2 +/- s.e. mean = 6.39 +/- 0.6) tended to be more potent than PGD2 (5.68 +/- 0.2). Since, in vivo, PGD2 has greater efficacy and potency than PGF2 alpha, our results suggest that the in vivo effect of these prostaglandins does not result solely from an action on airway muscle.
J L Black, and
C L Armour, and
K S Vincenc, and
P R Johnson
August 1989,
Prostaglandins,
J L Black, and
C L Armour, and
K S Vincenc, and
P R Johnson
August 1992,
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J L Black, and
C L Armour, and
K S Vincenc, and
P R Johnson
September 1980,
Nihon Kyobu Shikkan Gakkai zasshi,
J L Black, and
C L Armour, and
K S Vincenc, and
P R Johnson
January 1983,
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J L Black, and
C L Armour, and
K S Vincenc, and
P R Johnson
December 1982,
Prostaglandins,
J L Black, and
C L Armour, and
K S Vincenc, and
P R Johnson
January 1994,
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J L Black, and
C L Armour, and
K S Vincenc, and
P R Johnson
January 1989,
Progress in clinical and biological research,
J L Black, and
C L Armour, and
K S Vincenc, and
P R Johnson
August 1983,
Prostaglandins,
J L Black, and
C L Armour, and
K S Vincenc, and
P R Johnson
May 1990,
British journal of pharmacology,
J L Black, and
C L Armour, and
K S Vincenc, and
P R Johnson
January 1980,
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