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Pharmacokinetic and clinical studies of imipenem/cilastatin sodium (MK-0787/MK-0791), a newly developed combined antibiotic in a 1:1 ratio, were performed in the field of pediatrics. The MK-0787/MK-0791 was administered to 15 children. Ten and 20 mg/kg doses of MK-0787 were administered by a intravenous drip infusion for 30 minutes to 3 children each. In the remaining 9 cases, MK-0787 doses of 10, 20 and 30 mg/kg were administered to 3 children each by a 1 hour intravenous drip infusion. Levels of MK-0787 and MK-0791 in plasma, urine and urinary recovery rate of the drugs were also determined. In addition, MK-0787/MK-0791 was administered to a total of 29 children; 2 children with bronchitis, 16 with pneumonia, 4 with UTI, 2 with purulent lymphadenitis and 1 child each with tonsillitis, septicemia suspected disease, peritonitis, staphylococcal scalded skin syndrome and osteomyelitis/bacteremia. The average single dose was 15.3 mg/kg of MK-0787 and administrations were performed by 20-60 minutes intravenous drip infusion 3-4 times daily for an average period of 6 days. The clinical and bacteriological effects of this drug were evaluated in these cases and adverse reactions and unusual laboratory findings were also studied in a total of 33 cases including 4 other drop-out cases. Results of these studies were summarized as follows. In 6 children, 3 each who were given doses of 10 or 20 mg/kg, the mean peak plasma concentrations of the drugs were found at the end of the 30 minutes-infusion with values of 35.20 and 74.90 micrograms/ml for MK-0787 and 44.85 and 93.32 micrograms/ml for MK-0791 after the dose of 10 and 20 mg/kg, respectively. The peak plasma levels of MK-0791 were approximately 1.3 times higher than those of MK-0787 and higher peak levels were observed in the groups with larger doses of either drugs. In the 10 mg/kg group, the mean half-lives of MK-0787 and MK-0791 were 0.97 and 0.71 hour, respectively and those values were 0.89 and 0.63 hour, respectively in the 20 mg/kg group. In both group, MK-0787 tended to have longer half-lives than MK-0791. In 9 children, 3 each who were administered doses of 10, 20 and 30 mg/kg by a 1 hour intravenous drip infusion had the highest plasma levels for both MK-0787 and MK-0791 at the end of the infusion.(ABSTRACT TRUNCATED AT 400 WORDS)
T Motohiro, and
T Koga, and
Y Shimada, and
S Tomita, and
T Fujimoto, and
T Nishiyama, and
K Tominaga, and
F Yamashita, and
K Suzuki, and
O Toyoda
July 1986,
The Japanese journal of antibiotics,
T Motohiro, and
T Koga, and
Y Shimada, and
S Tomita, and
T Fujimoto, and
T Nishiyama, and
K Tominaga, and
F Yamashita, and
K Suzuki, and
O Toyoda
July 1986,
The Japanese journal of antibiotics,
T Motohiro, and
T Koga, and
Y Shimada, and
S Tomita, and
T Fujimoto, and
T Nishiyama, and
K Tominaga, and
F Yamashita, and
K Suzuki, and
O Toyoda
July 1986,
The Japanese journal of antibiotics,
T Motohiro, and
T Koga, and
Y Shimada, and
S Tomita, and
T Fujimoto, and
T Nishiyama, and
K Tominaga, and
F Yamashita, and
K Suzuki, and
O Toyoda
July 1986,
The Japanese journal of antibiotics,
T Motohiro, and
T Koga, and
Y Shimada, and
S Tomita, and
T Fujimoto, and
T Nishiyama, and
K Tominaga, and
F Yamashita, and
K Suzuki, and
O Toyoda
July 1986,
The Japanese journal of antibiotics,
T Motohiro, and
T Koga, and
Y Shimada, and
S Tomita, and
T Fujimoto, and
T Nishiyama, and
K Tominaga, and
F Yamashita, and
K Suzuki, and
O Toyoda
June 1986,
The Japanese journal of antibiotics,
T Motohiro, and
T Koga, and
Y Shimada, and
S Tomita, and
T Fujimoto, and
T Nishiyama, and
K Tominaga, and
F Yamashita, and
K Suzuki, and
O Toyoda
July 1986,
The Japanese journal of antibiotics,
T Motohiro, and
T Koga, and
Y Shimada, and
S Tomita, and
T Fujimoto, and
T Nishiyama, and
K Tominaga, and
F Yamashita, and
K Suzuki, and
O Toyoda
November 1988,
The Japanese journal of antibiotics,
T Motohiro, and
T Koga, and
Y Shimada, and
S Tomita, and
T Fujimoto, and
T Nishiyama, and
K Tominaga, and
F Yamashita, and
K Suzuki, and
O Toyoda
November 1988,
The Japanese journal of antibiotics,
T Motohiro, and
T Koga, and
Y Shimada, and
S Tomita, and
T Fujimoto, and
T Nishiyama, and
K Tominaga, and
F Yamashita, and
K Suzuki, and
O Toyoda
May 1989,
The Japanese journal of antibiotics,
