BIOMAT Database Logo BIOMAT Database Logo

Human Amniotic Epithelial Stem Cell-Derived Retinal Pigment Epithelium Cells Repair Retinal Degeneration. 2021

Jinying Li, and Chen Qiu, and Yang Wei, and Weixin Yuan, and Jia Liu, and Wenyu Cui, and Jiayi Zhou, and Cong Qiu, and Lihe Guo, and Liquan Huang, and Zhen Ge, and Luyang Yu
Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province of Sir Run Run Shaw Hospital, MOE Laboratory of Biosystems Homeostasis & Protection of College of Life Sciences, Zhejiang University, Hangzhou, China.

Age-related macular degeneration (AMD), featured with dysfunction and loss of retinal pigment epithelium (RPE), is lacking efficient therapeutic approaches. According to our previous studies, human amniotic epithelial stem cells (hAESCs) may serve as a potential seed cell source of RPE cells for therapy because they have no ethical concerns, no tumorigenicity, and little immunogenicity. Herein, trichostatin A and nicotinamide can direct hAESCs differentiation into RPE like cells. The differentiated cells display the morphology, marker expression and cellular function of the native RPE cells, and noticeably express little MHC class II antigens and high level of HLA-G. Moreover, visual function and retinal structure of Royal College of Surgeon (RCS) rats, a classical animal model of retinal degeneration, were rescued after subretinal transplantation with the hAESCs-derived RPE like cells. Our study possibly makes some contribution to the resource of functional RPE cells for cell therapy. Subretinal transplantation of hAESCs-RPE could be an optional therapeutic strategy for retinal degeneration diseases.

UI MeSH Term Description Entries

Related Publications

Jinying Li, and Chen Qiu, and Yang Wei, and Weixin Yuan, and Jia Liu, and Wenyu Cui, and Jiayi Zhou, and Cong Qiu, and Lihe Guo, and Liquan Huang, and Zhen Ge, and Luyang Yu
Embryonic stem-cell-derived retinal pigment epithelial cells for macular degeneration.
June 2012, Lancet (London, England),
Jinying Li, and Chen Qiu, and Yang Wei, and Weixin Yuan, and Jia Liu, and Wenyu Cui, and Jiayi Zhou, and Cong Qiu, and Lihe Guo, and Liquan Huang, and Zhen Ge, and Luyang Yu
Embryonic stem-cell-derived retinal pigment epithelial cells for macular degeneration.
June 2012, Lancet (London, England),
Jinying Li, and Chen Qiu, and Yang Wei, and Weixin Yuan, and Jia Liu, and Wenyu Cui, and Jiayi Zhou, and Cong Qiu, and Lihe Guo, and Liquan Huang, and Zhen Ge, and Luyang Yu
Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in Macular Degeneration.
November 2018, Ophthalmology,
Jinying Li, and Chen Qiu, and Yang Wei, and Weixin Yuan, and Jia Liu, and Wenyu Cui, and Jiayi Zhou, and Cong Qiu, and Lihe Guo, and Liquan Huang, and Zhen Ge, and Luyang Yu
Retinal pigment epithelium derived stem cells.
July 2009, Journal of ophthalmic & vision research,
Jinying Li, and Chen Qiu, and Yang Wei, and Weixin Yuan, and Jia Liu, and Wenyu Cui, and Jiayi Zhou, and Cong Qiu, and Lihe Guo, and Liquan Huang, and Zhen Ge, and Luyang Yu
Transcriptional comparison of adult human primary Retinal Pigment Epithelium, human pluripotent stem cell-derived Retinal Pigment Epithelium, and ARPE19 cells.
January 2022, Frontiers in cell and developmental biology,
Jinying Li, and Chen Qiu, and Yang Wei, and Weixin Yuan, and Jia Liu, and Wenyu Cui, and Jiayi Zhou, and Cong Qiu, and Lihe Guo, and Liquan Huang, and Zhen Ge, and Luyang Yu
Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells (MA09-hRPE) in macular degeneration.
January 2019, NPJ Regenerative medicine,
Jinying Li, and Chen Qiu, and Yang Wei, and Weixin Yuan, and Jia Liu, and Wenyu Cui, and Jiayi Zhou, and Cong Qiu, and Lihe Guo, and Liquan Huang, and Zhen Ge, and Luyang Yu
IKKβ Inhibition Attenuates Epithelial Mesenchymal Transition of Human Stem Cell-Derived Retinal Pigment Epithelium.
April 2023, Cells,
Jinying Li, and Chen Qiu, and Yang Wei, and Weixin Yuan, and Jia Liu, and Wenyu Cui, and Jiayi Zhou, and Cong Qiu, and Lihe Guo, and Liquan Huang, and Zhen Ge, and Luyang Yu
Human umbilical tissue-derived cells rescue retinal pigment epithelium dysfunction in retinal degeneration.
February 2016, Stem cells (Dayton, Ohio),
Jinying Li, and Chen Qiu, and Yang Wei, and Weixin Yuan, and Jia Liu, and Wenyu Cui, and Jiayi Zhou, and Cong Qiu, and Lihe Guo, and Liquan Huang, and Zhen Ge, and Luyang Yu
A Preclinical Safety Study of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells for Macular Degeneration.
January 2020, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics,
Jinying Li, and Chen Qiu, and Yang Wei, and Weixin Yuan, and Jia Liu, and Wenyu Cui, and Jiayi Zhou, and Cong Qiu, and Lihe Guo, and Liquan Huang, and Zhen Ge, and Luyang Yu
Efflux protein expression in human stem cell-derived retinal pigment epithelial cells.
January 2012, PloS one,
Copied contents to your clipboard!