Biomaterial Database

Prostaglandin (F2 alpha) in missed abortion. Intravenous, extra-amniotic and intramuscular administration--a randomized study. 1986

A S Thavarasah, and S A Almohdzar

Prostaglandin F2-alpha was administered by the intravenous, extra-amniotic and intramuscular routes in three comparable groups of patients with missed abortion, during a randomized study. Out of 45 patients (15 in each group), nine patients (60%) of the intravenous group aborted within a mean time of 16.2 hours, whereas 14 patients (93.4%) of the extra-amniotic group and 12 patients (80%) of the intramuscular group aborted in averaged times of 8.2 and 10.6 hours, respectively. The percentage of complete abortions was highest in the intravenous group 88.8%, followed by the intramuscular group (50%), and the extra-amniotic group (35.7%). Side effects of nausea, vomiting, diarrhoea and shivering were observed in all groups studied, but were marginally higher in the intravenous group.

UI	MeSH Term	Description	Entries
D007262	Infusions, Intravenous	The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.	Drip Infusions,Intravenous Drip,Intravenous Infusions,Drip Infusion,Drip, Intravenous,Infusion, Drip,Infusion, Intravenous,Infusions, Drip,Intravenous Infusion
D007267	Injections	Introduction of substances into the body using a needle and syringe.	Injectables,Injectable,Injection
D007273	Injections, Intramuscular	Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.	Intramuscular Injections,Injection, Intramuscular,Intramuscular Injection
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011460	Prostaglandins F	(9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.	PGF
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000030	Abortion, Missed	The retention in the UTERUS of a dead FETUS two months or more after its DEATH.	Abortions, Missed,Missed Abortion,Missed Abortions
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000650	Amnion	The innermost membranous sac that surrounds and protects the developing embryo which is bathed in the AMNIOTIC FLUID. Amnion cells are secretory EPITHELIAL CELLS and contribute to the amniotic fluid.	Amniotic Membrane,Amnions,Amniotic Membranes,Membrane, Amniotic,Membranes, Amniotic