Biomaterial Database

Role of glutathione in reversing the deleterious effects of a thiol-oxidizing agent in Escherichia coli. 1978

K A Hibberd, and P B Berget, and H R Warner, and J A Fuchs

Diamide was found to be much less specific for the oxidation of glutathione in vivo in Escherichia coli than had been previously assumed. In vivo, only a slight alteration of the ratio of reduced to oxidized glutathione was found, whereas a significant amount of glutathione was found in the form of mixed disulfide with proteins. This latter occurrence was postulated as being responsible for the bacteriostatic effect of diamide.

UI	MeSH Term	Description	Entries
D003958	Diamide	A sulfhydryl reagent which oxidizes sulfhydryl groups to the disulfide form. It is a radiation-sensitizing agent of anoxic bacterial and mammalian cells.	Diazodicarboxylic Acid Bis(N,N-dimethyl)amide,Diazodicarboxylic Acid Bisdimethylamide,Dizene Dicarboxylic Acid Bis(N,N-dimethylamide),Dizenedicarboxylic Acid Bis(N,N-dimethylamide),Tetramethylazoformamide,Acid Bisdimethylamide, Diazodicarboxylic,Bisdimethylamide, Diazodicarboxylic Acid
D004220	Disulfides	Chemical groups containing the covalent disulfide bonds -S-S-. The sulfur atoms can be bound to inorganic or organic moieties.	Disulfide
D004926	Escherichia coli	A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.	Alkalescens-Dispar Group,Bacillus coli,Bacterium coli,Bacterium coli commune,Diffusely Adherent Escherichia coli,E coli,EAggEC,Enteroaggregative Escherichia coli,Enterococcus coli,Diffusely Adherent E. coli,Enteroaggregative E. coli,Enteroinvasive E. coli,Enteroinvasive Escherichia coli
D005978	Glutathione	A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.	Reduced Glutathione,gamma-L-Glu-L-Cys-Gly,gamma-L-Glutamyl-L-Cysteinylglycine,Glutathione, Reduced,gamma L Glu L Cys Gly,gamma L Glutamyl L Cysteinylglycine
D001391	Azo Compounds	Organic chemicals where aryl or alkyl groups are joined by two nitrogen atoms through a double bond (R-N	Azo Dye,Azo Dyes,Compounds, Azo,Dye, Azo,Dyes, Azo
D013438	Sulfhydryl Compounds	Compounds containing the -SH radical.	Mercaptan,Mercapto Compounds,Sulfhydryl Compound,Thiol,Thiols,Mercaptans,Compound, Sulfhydryl,Compounds, Mercapto,Compounds, Sulfhydryl