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Pharmacokinetics and clinical studies on cefotiam (CTM) in pediatric surgery were performed and the results obtained are summarized below. In neonates without congenital heart disease (CHD), serum levels of CTM were rapidly increased following injection of CTM (20 mg/kg, one shot intravenous administration) and the peak values were found at 15 minutes. Six hours later, CTM almost disappeared from the blood. In the patient with CHD, however, CTM was retained in the serum and the urinary excretion was poor. The CTM was administrated prophylactically to prevent postoperative infections in 10 patients. Eight of 10 had no episodes during postoperative period. Wound infection, however, was found in 2 patients. No clinical and laboratory side effects were caused by CTM.
J Yura, and
N Tsuruga, and
T Hashimoto, and
Y Kamiya, and
S Hayashi, and
Y Murata
September 1989,
Clinical pharmacokinetics,
J Yura, and
N Tsuruga, and
T Hashimoto, and
Y Kamiya, and
S Hayashi, and
Y Murata
June 1981,
The Japanese journal of antibiotics,
J Yura, and
N Tsuruga, and
T Hashimoto, and
Y Kamiya, and
S Hayashi, and
Y Murata
January 1997,
Infection,
J Yura, and
N Tsuruga, and
T Hashimoto, and
Y Kamiya, and
S Hayashi, and
Y Murata
February 1985,
Antimicrobial agents and chemotherapy,
J Yura, and
N Tsuruga, and
T Hashimoto, and
Y Kamiya, and
S Hayashi, and
Y Murata
May 1982,
The Japanese journal of antibiotics,
J Yura, and
N Tsuruga, and
T Hashimoto, and
Y Kamiya, and
S Hayashi, and
Y Murata
December 1982,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
J Yura, and
N Tsuruga, and
T Hashimoto, and
Y Kamiya, and
S Hayashi, and
Y Murata
December 1982,
Antimicrobial agents and chemotherapy,
J Yura, and
N Tsuruga, and
T Hashimoto, and
Y Kamiya, and
S Hayashi, and
Y Murata
July 1986,
International journal of clinical pharmacology, therapy, and toxicology,
J Yura, and
N Tsuruga, and
T Hashimoto, and
Y Kamiya, and
S Hayashi, and
Y Murata
March 1983,
The Japanese journal of antibiotics,
J Yura, and
N Tsuruga, and
T Hashimoto, and
Y Kamiya, and
S Hayashi, and
Y Murata
June 1981,
The Japanese journal of antibiotics,
