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Recently, we described the presence of six immunoreactive (ir) morphinans in bovine adrenal and hypothalamus and identified one as morphine [Goldstein, A., Barrett, R. W., James, I. F., Lowney, L. I., Weitz, C. J., Knipmeyer, L. L. & Rapaport, H. (1985) Proc. Natl. Acad. Sci. USA 82, 5203-5207]. We now report that ir morphinans corresponding to the previously reported peak 1 (morphine), peak 4, and peak 5 are consistently present in extracts of bovine hypothalamus and variably present in extracts of bovine adrenal and rat brain. We no longer detect the previously reported peaks 2, 3, or 6, and we have established that they were contamination artifacts. Peak 1 is coeluted with morphine in two distinct reversed-phase HPLC systems, as is peak 4 with codeine. We have purified peak 1 and peak 4 compounds from bovine hypothalamus and determined their identities by gas chromatography/mass spectrometry (GC/MS): peak 1 is confirmed to be morphine and peak 4 is codeine.
C J Weitz, and
L I Lowney, and
K F Faull, and
G Feistner, and
A Goldstein
January 1990,
Life sciences,
C J Weitz, and
L I Lowney, and
K F Faull, and
G Feistner, and
A Goldstein
January 1964,
Acta pharmacologica et toxicologica,
C J Weitz, and
L I Lowney, and
K F Faull, and
G Feistner, and
A Goldstein
July 2009,
Pharmacogenetics and genomics,
C J Weitz, and
L I Lowney, and
K F Faull, and
G Feistner, and
A Goldstein
January 2011,
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,
C J Weitz, and
L I Lowney, and
K F Faull, and
G Feistner, and
A Goldstein
January 1981,
Beitrage zur gerichtlichen Medizin,
C J Weitz, and
L I Lowney, and
K F Faull, and
G Feistner, and
A Goldstein
November 1993,
Brain research,
C J Weitz, and
L I Lowney, and
K F Faull, and
G Feistner, and
A Goldstein
November 1975,
Journal of medicinal chemistry,
C J Weitz, and
L I Lowney, and
K F Faull, and
G Feistner, and
A Goldstein
June 2004,
Medical science monitor : international medical journal of experimental and clinical research,
C J Weitz, and
L I Lowney, and
K F Faull, and
G Feistner, and
A Goldstein
August 1977,
Research communications in chemical pathology and pharmacology,
C J Weitz, and
L I Lowney, and
K F Faull, and
G Feistner, and
A Goldstein
October 1889,
Buffalo medical and surgical journal,
