Comparison between 200 μg and 800 μg of vaginal misoprostol for cervical ripening before operative hysteroscopy: A randomized controlled trial. 2022

Maria da Conceição Farias Souto Maior, and Alex Sandro Rolland Souza, and Gustavo Fonseca de Albuquerque Souza, and Aurélio Antônio Ribeiro da Costa
Postgraduate Program in Integral Health, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil.

OBJECTIVE To compare between 200 and 800 μg of vaginal misoprostol for cervical ripening before operative hysteroscopy. METHODS Quadruple-blind randomized clinical trial conducted between November 2019 and September 2020 involving 76 patients undergoing cervical dilatation before surgical hysteroscopy at teaching hospitals in Pernambuco, Brazil. Women received the vaginal misoprostol dosage of 200 or 800 μg,10-12 h before operative hysteroscopy. The cervical width was the primary outcome, and secondary outcomes were patient satisfaction, adverse effects, surgical complications, and duration of cervical dilatation. Chi-square tests of association, Fisher's exact and Mann-Whitney U tests were used with an α error of <5%. RESULTS There was no statistical difference between the groups in the mean of the cervical width (800 μg: 6.5 ± 1.6 mm vs 200 μg: 5.8 ± 1.8 mm, P = 0.055), patient satisfaction, and surgical findings, but the duration of cervical dilatation was lower in the 800-μg group (28.16 ± 28.5 s vs 41.97 ± 31.0 s, P = 0.035). Among the adverse effects, diarrhea was more frequent in the 800-μg group with statistical difference (100% vs 0%; P = 0.01). CONCLUSIONS For cervical ripening, 200 μg misoprostol is equally effective with fewer adverse effects than 800 μg before operative hysteroscopy. RESULTS gov: NCT04152317. https://clinicaltrials.gov/ct2/show/NCT04152317.

UI MeSH Term Description Entries
D010120 Oxytocics Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157) Oxytocic,Oxytocic Agent,Oxytocic Drug,Uterine Stimulant,Uterine Stimulants,Oxytocic Agents,Oxytocic Drugs,Oxytocic Effect,Oxytocic Effects,Agent, Oxytocic,Agents, Oxytocic,Drug, Oxytocic,Drugs, Oxytocic,Effect, Oxytocic,Effects, Oxytocic,Stimulant, Uterine,Stimulants, Uterine
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011300 Preoperative Care Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed) Care, Preoperative,Preoperative Procedure,Preoperative Procedures,Procedure, Preoperative,Procedures, Preoperative
D002584 Cervix Uteri The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal. Cervical Canal of the Uterus,Cervical Canal, Uterine,Ectocervix,Endocervical Canal,Endocervix,External Os Cervix,External Os of the Cervix,Uterine Cervical Canal,Cervix,Cervixes,Uterine Cervix,Canal, Endocervical,Canal, Uterine Cervical,Cervix, External Os,Cervix, Uterine,Endocervical Canals,Uterine Cervical Canals
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000282 Administration, Intravaginal The insertion of drugs into the vagina to treat local infections, neoplasms, or to induce labor. The dosage forms may include medicated pessaries, irrigation fluids, and suppositories. Administration, Vaginal,Drug Administration, Vaginal,Instillation, Vaginal,Intravaginal Administration,Vaginal Drug Administration,Vaginal Administration,Administration, Vaginal Drug,Administrations, Intravaginal,Administrations, Vaginal,Administrations, Vaginal Drug,Drug Administrations, Vaginal,Instillations, Vaginal,Intravaginal Administrations,Vaginal Administrations,Vaginal Drug Administrations,Vaginal Instillation,Vaginal Instillations
D015907 Hysteroscopy Endoscopic examination, therapy or surgery of the interior of the uterus. Endoscopy, Uterine,Hysteroscopic Surgical Procedures,Surgical Procedures, Hysteroscopic,Uterine Endoscopy,Hysteroscopic Surgery,Surgery, Hysteroscopic,Uteroscopy,Endoscopies, Uterine,Hysteroscopic Surgeries,Hysteroscopic Surgical Procedure,Hysteroscopies,Procedure, Hysteroscopic Surgical,Procedures, Hysteroscopic Surgical,Surgeries, Hysteroscopic,Surgical Procedure, Hysteroscopic,Uterine Endoscopies,Uteroscopies
D016595 Misoprostol A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties. Apo-Misoprostol,Cytotec,Glefos,Misoprostol, (11alpha,13E)-Isomer,Misoprostol, (11alpha,13E,16R)-Isomer,Misoprostol, (11alpha,13Z)-(+-)-Isomer,Misoprostol, (11alpha.13E,16S)-Isomer,Misoprostol, (11beta,13E)-(+-)-Isomer,Misoprostol, (11beta,13E,16R)-Isomer,Misoprostol, (11beta,13E,16S)-Isomer,Novo-Misoprostol,SC-29333,SC-30249,Apo Misoprostol,Novo Misoprostol,SC 29333,SC 30249,SC29333,SC30249

Related Publications

Maria da Conceição Farias Souto Maior, and Alex Sandro Rolland Souza, and Gustavo Fonseca de Albuquerque Souza, and Aurélio Antônio Ribeiro da Costa
December 2000, Obstetrics and gynecology,
Maria da Conceição Farias Souto Maior, and Alex Sandro Rolland Souza, and Gustavo Fonseca de Albuquerque Souza, and Aurélio Antônio Ribeiro da Costa
April 2001, Obstetrics and gynecology,
Maria da Conceição Farias Souto Maior, and Alex Sandro Rolland Souza, and Gustavo Fonseca de Albuquerque Souza, and Aurélio Antônio Ribeiro da Costa
May 2013, Archives of gynecology and obstetrics,
Maria da Conceição Farias Souto Maior, and Alex Sandro Rolland Souza, and Gustavo Fonseca de Albuquerque Souza, and Aurélio Antônio Ribeiro da Costa
January 2008, Journal of minimally invasive gynecology,
Maria da Conceição Farias Souto Maior, and Alex Sandro Rolland Souza, and Gustavo Fonseca de Albuquerque Souza, and Aurélio Antônio Ribeiro da Costa
September 1999, Obstetrics and gynecology,
Maria da Conceição Farias Souto Maior, and Alex Sandro Rolland Souza, and Gustavo Fonseca de Albuquerque Souza, and Aurélio Antônio Ribeiro da Costa
April 2008, Fertility and sterility,
Maria da Conceição Farias Souto Maior, and Alex Sandro Rolland Souza, and Gustavo Fonseca de Albuquerque Souza, and Aurélio Antônio Ribeiro da Costa
December 2019, Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy,
Maria da Conceição Farias Souto Maior, and Alex Sandro Rolland Souza, and Gustavo Fonseca de Albuquerque Souza, and Aurélio Antônio Ribeiro da Costa
January 2016, Journal of minimally invasive gynecology,
Maria da Conceição Farias Souto Maior, and Alex Sandro Rolland Souza, and Gustavo Fonseca de Albuquerque Souza, and Aurélio Antônio Ribeiro da Costa
September 2019, Maedica,
Maria da Conceição Farias Souto Maior, and Alex Sandro Rolland Souza, and Gustavo Fonseca de Albuquerque Souza, and Aurélio Antônio Ribeiro da Costa
October 2011, Fertility and sterility,
Copied contents to your clipboard!