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Several sets of data indicate the possibility that carbohydrate moieties on the target cell are important structures in natural killer (NK) cell-mediated lysis. Striking changes in the NK susceptibility of targets can be induced in several systems involving in vitro differentiation of tumour cell lines. The effect on target cells of the glycosylation inhibitor tunicamycin, which acts by blocking the dolichol-dependent asparagine-linked glycosylation pathway was investigated. Using several different tumour cell lines we can conclude that: asparagine-linked carbohydrate chains do not contribute directly to NK susceptibility, induced differentiation may or may not be linked with a change in NK susceptibility, and secondary changes caused by tunicamycin treatment may lead to alterations in the gangliosides, a finding that is positively correlated with decreased NK susceptibility.
M Nose, and
M Gidlund, and
Z Hosein, and
I Axberg, and
H Wigzell, and
G Yogeeswaran
May 1980,
Journal of immunology (Baltimore, Md. : 1950),
M Nose, and
M Gidlund, and
Z Hosein, and
I Axberg, and
H Wigzell, and
G Yogeeswaran
March 2002,
Blood,
M Nose, and
M Gidlund, and
Z Hosein, and
I Axberg, and
H Wigzell, and
G Yogeeswaran
September 1990,
Cancer research,
M Nose, and
M Gidlund, and
Z Hosein, and
I Axberg, and
H Wigzell, and
G Yogeeswaran
September 1998,
Immunology letters,
M Nose, and
M Gidlund, and
Z Hosein, and
I Axberg, and
H Wigzell, and
G Yogeeswaran
June 1987,
Cancer research,
M Nose, and
M Gidlund, and
Z Hosein, and
I Axberg, and
H Wigzell, and
G Yogeeswaran
January 2012,
Evidence-based complementary and alternative medicine : eCAM,
M Nose, and
M Gidlund, and
Z Hosein, and
I Axberg, and
H Wigzell, and
G Yogeeswaran
January 1987,
Journal of immunology (Baltimore, Md. : 1950),
M Nose, and
M Gidlund, and
Z Hosein, and
I Axberg, and
H Wigzell, and
G Yogeeswaran
May 1980,
International journal of cancer,
M Nose, and
M Gidlund, and
Z Hosein, and
I Axberg, and
H Wigzell, and
G Yogeeswaran
September 1989,
Immunology letters,
M Nose, and
M Gidlund, and
Z Hosein, and
I Axberg, and
H Wigzell, and
G Yogeeswaran
January 1983,
Haematology and blood transfusion,
