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It has been suggested that the expression of some HLA class II antigens, derived from three loci (DR, DP, DQ) is important in the regulation of both the immune response and the response of haemopoietic progenitors to regulation factors, such as acidic isoferritins (AIF), as well as in the interaction between T lymphocytes and erythroid progenitors (BFU-E). Changes in the expression of class II antigens have been reported on the surface of granulo-monocyte progenitors in chronic myeloid leukemia (CML) and correlated to the abnormal proliferation of such cells. In this study, monoclonal antibodies against DR and DQ monomorphic determinants were used to investigate the expression of these antigens on the surface of normal and CML bone marrow and peripheral blood BFU-E by means of complement mediated cytotoxicity. It was found that most normal and leukemic BFU-E express DR antigens. Antigens density tends to be greater on marrow as opposed to peripheral precursors. In addition, leukemic BFU-E are more sensitive to cytolytic treatment than their normal counterparts. Normal BFU-E do not express detectable amounts of DQ antigens, whereas these are present on a proportion of leukemic BFU-E.
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M Aglietta, and
A Stacchini, and
P Spinelli, and
L Salvetti, and
S Kerim, and
F Malavasi, and
V Infelise, and
L Resegotti, and
F Gavosto
October 1992,
Blood,
W Piacibello, and
M Aglietta, and
A Stacchini, and
P Spinelli, and
L Salvetti, and
S Kerim, and
F Malavasi, and
V Infelise, and
L Resegotti, and
F Gavosto
January 1990,
Regional immunology,
W Piacibello, and
M Aglietta, and
A Stacchini, and
P Spinelli, and
L Salvetti, and
S Kerim, and
F Malavasi, and
V Infelise, and
L Resegotti, and
F Gavosto
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W Piacibello, and
M Aglietta, and
A Stacchini, and
P Spinelli, and
L Salvetti, and
S Kerim, and
F Malavasi, and
V Infelise, and
L Resegotti, and
F Gavosto
December 1997,
Blood,
W Piacibello, and
M Aglietta, and
A Stacchini, and
P Spinelli, and
L Salvetti, and
S Kerim, and
F Malavasi, and
V Infelise, and
L Resegotti, and
F Gavosto
October 2002,
Blood,
W Piacibello, and
M Aglietta, and
A Stacchini, and
P Spinelli, and
L Salvetti, and
S Kerim, and
F Malavasi, and
V Infelise, and
L Resegotti, and
F Gavosto
May 1990,
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W Piacibello, and
M Aglietta, and
A Stacchini, and
P Spinelli, and
L Salvetti, and
S Kerim, and
F Malavasi, and
V Infelise, and
L Resegotti, and
F Gavosto
January 1988,
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W Piacibello, and
M Aglietta, and
A Stacchini, and
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L Salvetti, and
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F Malavasi, and
V Infelise, and
L Resegotti, and
F Gavosto
January 1990,
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W Piacibello, and
M Aglietta, and
A Stacchini, and
P Spinelli, and
L Salvetti, and
S Kerim, and
F Malavasi, and
V Infelise, and
L Resegotti, and
F Gavosto
September 1992,
Journal of immunology (Baltimore, Md. : 1950),
W Piacibello, and
M Aglietta, and
A Stacchini, and
P Spinelli, and
L Salvetti, and
S Kerim, and
F Malavasi, and
V Infelise, and
L Resegotti, and
F Gavosto
May 2007,
Stem cells (Dayton, Ohio),
