Biomaterial Database

Verbal Amnesia Secondary to Unilateral Infarct of the Mediodorsal Thalamic Nucleus. 2021

Haley Pysick, and Donn Dexter, and Christopher Lindsay

Department of Internal Medicine, University of Iowa Hospital and Clinics, Iowa City, Iowa.

BACKGROUND The mediodorsal nucleus is a subcomponent of the thalamus hypothesized to have a role in memory pathways. Given the limited number of reported cases and associated images, its clinical significance has not yet been fully elucidated. METHODS We report the case of a 53-year-old man who presented with verbal amnesia, including deficits of both recall and recognition. High-resolution magnetic resonance imaging demonstrated a well-defined infarct contained within the mediodorsal nucleus. CONCLUSIONS Current literature reports a range of conclusions regarding the extent to which the mediodorsal nucleus is involved in memory pathways. Several case series have attempted to localize infarcts by combining neuropsychology testing with imaging but were constrained by dated imaging modalities often dispersed with impurities. CONCLUSIONS Our case demonstrates that isolated lesions of the mediodorsal nucleus can lead to deficits in both recall and recognition and that high-resolution magnetic resonance imaging is necessary when a thalamic infarct is suspected.

UI	MeSH Term	Description	Entries
D007238	Infarction	Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most commonly by a THROMBUS or EMBOLUS.	Infarct,Infarctions,Infarcts
D008279	Magnetic Resonance Imaging	Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.	Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000647	Amnesia	Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)	Amnesia, Dissociative,Amnesia, Global,Amnesia, Hysterical,Amnesia, Tactile,Amnesia, Temporary,Amnesia-Memory Loss,Amnestic State,Amnesia Memory Loss,Amnesia-Memory Losses,Amnesias,Amnesias, Dissociative,Amnesias, Global,Amnesias, Hysterical,Amnesias, Tactile,Amnesias, Temporary,Amnestic States,Dissociative Amnesia,Dissociative Amnesias,Global Amnesia,Global Amnesias,Hysterical Amnesia,Hysterical Amnesias,State, Amnestic,States, Amnestic,Tactile Amnesia,Tactile Amnesias,Temporary Amnesia,Temporary Amnesias
D013788	Thalamus	Paired bodies containing mostly GRAY MATTER and forming part of the lateral wall of the THIRD VENTRICLE of the brain.	Thalamencephalon,Thalamencephalons
D020645	Mediodorsal Thalamic Nucleus	The largest of the medial nuclei of the thalamus. It makes extensive connections with most of the other thalamic nuclei.	Dorsal Medial Nucleus,Dorsomedial Thalamic Nucleus,Medial Dorsal Nucleus,Dorsomedial Nucleus,Medial Dorsal Thalamic Nucleus,Medial Thalamic Nuclei,Medial Thalamic Nucleus,Mediodorsal Nucleus,Nucleus Dorsomedialis Thalami,Nucleus Medialis Dorsalis,Dorsali, Nucleus Medialis,Dorsalis, Nucleus Medialis,Dorsomedialis Thalami, Nucleus,Dorsomedialis Thalamus, Nucleus,Medialis Dorsali, Nucleus,Medialis Dorsalis, Nucleus,Nuclei, Medial Thalamic,Nucleus Dorsomedialis Thalamus,Nucleus Medialis Dorsali,Nucleus, Dorsal Medial,Nucleus, Dorsomedial,Nucleus, Dorsomedial Thalamic,Nucleus, Medial Dorsal,Nucleus, Medial Thalamic,Nucleus, Mediodorsal,Nucleus, Mediodorsal Thalamic,Thalami, Nucleus Dorsomedialis,Thalamic Nuclei, Medial,Thalamic Nucleus, Dorsomedial,Thalamic Nucleus, Medial,Thalamic Nucleus, Mediodorsal,Thalamus, Nucleus Dorsomedialis