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We recently reported the isolation of a new retrovirus, termed human immunodeficiency virus type 2 (HIV-2), from two West African patients with the acquired immunodeficiency syndrome (AIDS). This virus is related to but distinct from the well-characterized AIDS retrovirus, human immunodeficiency virus type 1 (HIV-1). We report here evidence of infection with HIV-2 in 30 patients, almost all from West Africa. Seventeen of them had a clinical syndrome indistinguishable from AIDS (7 of these 17 died). Others had either the AIDS-related complex or no HIV-related symptoms. All patients had serum antibodies reacting with HIV-2 in an indirect immunofluorescence assay. All serum tested contained antibodies reacting with the envelope glycoprotein of the virus in an immunoprecipitation assay. Cross-reactivity of serum antibodies with HIV-1 was detected in a minority of patients and varied according to the assay used. Retroviral isolates were obtained from the blood lymphocytes of 11 patients and were all identified as HIV-2 by nucleic acid hybridization; none hybridized with an HIV-1 probe. These findings indicate that some cases of AIDS in West Africa may be caused by HIV-2, but the extent of the spread of this virus and its clinical correlates will require careful epidemiologic investigation.
F Clavel, and
K Mansinho, and
S Chamaret, and
D Guetard, and
V Favier, and
J Nina, and
M O Santos-Ferreira, and
J L Champalimaud, and
L Montagnier
January 1988,
Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie,
F Clavel, and
K Mansinho, and
S Chamaret, and
D Guetard, and
V Favier, and
J Nina, and
M O Santos-Ferreira, and
J L Champalimaud, and
L Montagnier
January 1995,
International journal of STD & AIDS,
F Clavel, and
K Mansinho, and
S Chamaret, and
D Guetard, and
V Favier, and
J Nina, and
M O Santos-Ferreira, and
J L Champalimaud, and
L Montagnier
May 2014,
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F Clavel, and
K Mansinho, and
S Chamaret, and
D Guetard, and
V Favier, and
J Nina, and
M O Santos-Ferreira, and
J L Champalimaud, and
L Montagnier
April 1989,
Lancet (London, England),
F Clavel, and
K Mansinho, and
S Chamaret, and
D Guetard, and
V Favier, and
J Nina, and
M O Santos-Ferreira, and
J L Champalimaud, and
L Montagnier
October 1989,
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F Clavel, and
K Mansinho, and
S Chamaret, and
D Guetard, and
V Favier, and
J Nina, and
M O Santos-Ferreira, and
J L Champalimaud, and
L Montagnier
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F Clavel, and
K Mansinho, and
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D Guetard, and
V Favier, and
J Nina, and
M O Santos-Ferreira, and
J L Champalimaud, and
L Montagnier
May 1987,
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F Clavel, and
K Mansinho, and
S Chamaret, and
D Guetard, and
V Favier, and
J Nina, and
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J L Champalimaud, and
L Montagnier
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F Clavel, and
K Mansinho, and
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J L Champalimaud, and
L Montagnier
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F Clavel, and
K Mansinho, and
S Chamaret, and
D Guetard, and
V Favier, and
J Nina, and
M O Santos-Ferreira, and
J L Champalimaud, and
L Montagnier
September 1993,
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