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In order to determine on which chromosome the gene controlling human cytochrome P-450 (debrisoquine/sparteine type) is located a linkage study of polymorphic sparteine oxidation (PSO) to various polymorphic markers was carried out. Positive information for linkage between PSO and the P1 blood group was obtained with a maximal LOD-score of LOD = 3.35 for both male and female recombination fraction estimates of theta m = theta f = 0.0. The P1 blood group has been recently mapped to the long arm of chromosome 22. Thus it can be concluded that the gene controlling human cytochrome P-450 (debrisoquine/sparteine) is situated on the long arm of chromosome 22 in close vicinity to P1.
M Eichelbaum, and
M P Baur, and
H J Dengler, and
B O Osikowska-Evers, and
G Tieves, and
C Zekorn, and
C Rittner
July 1984,
Canadian journal of physiology and pharmacology,
M Eichelbaum, and
M P Baur, and
H J Dengler, and
B O Osikowska-Evers, and
G Tieves, and
C Zekorn, and
C Rittner
March 1985,
Nucleic acids research,
M Eichelbaum, and
M P Baur, and
H J Dengler, and
B O Osikowska-Evers, and
G Tieves, and
C Zekorn, and
C Rittner
July 1985,
Somatic cell and molecular genetics,
M Eichelbaum, and
M P Baur, and
H J Dengler, and
B O Osikowska-Evers, and
G Tieves, and
C Zekorn, and
C Rittner
September 1986,
Biochemical pharmacology,
M Eichelbaum, and
M P Baur, and
H J Dengler, and
B O Osikowska-Evers, and
G Tieves, and
C Zekorn, and
C Rittner
June 1978,
Human genetics,
M Eichelbaum, and
M P Baur, and
H J Dengler, and
B O Osikowska-Evers, and
G Tieves, and
C Zekorn, and
C Rittner
October 1988,
Biochemical pharmacology,
M Eichelbaum, and
M P Baur, and
H J Dengler, and
B O Osikowska-Evers, and
G Tieves, and
C Zekorn, and
C Rittner
October 1985,
Annals of human genetics,
M Eichelbaum, and
M P Baur, and
H J Dengler, and
B O Osikowska-Evers, and
G Tieves, and
C Zekorn, and
C Rittner
September 1986,
The Journal of biological chemistry,
M Eichelbaum, and
M P Baur, and
H J Dengler, and
B O Osikowska-Evers, and
G Tieves, and
C Zekorn, and
C Rittner
November 1986,
Science (New York, N.Y.),
M Eichelbaum, and
M P Baur, and
H J Dengler, and
B O Osikowska-Evers, and
G Tieves, and
C Zekorn, and
C Rittner
July 1986,
Annals of human genetics,
