-transparent.png){kind=logo}
Normal, castrate and estradiol benzoate (EB; 1 microgram/100 g b.w. x 6d, s.c.)-treated castrate male rats were utilized to study the short term effects of these treatments upon the incorporation of 3H-glycine into LH-RH in vitro. The rise in serum LH and FSH observed in the untreated castrates was prevented by EB therapy. The treatment had no significant effect upon serum LH-RH levels or the incorporation of 3H-gly into LH-RH. EB treatment markedly (p less than 0.01) increased the hypothalamic LH-RH concentration and significantly lowered the specific activity (nCi/ng) of the 3H-gly-LH-RH (p less than 0.05). These results suggest that EB acts both on the pituitary and hypothalamus to suppress gonadotropin (Gn) release, but that, at the time period studied, neither castration or EB-treatment had any apparent effect upon hypothalamic LH-RH synthesis.
R W Hall, and
E Steinberger
December 1977,
Revista espanola de fisiologia,
R W Hall, and
E Steinberger
June 1978,
Revista espanola de fisiologia,
R W Hall, and
E Steinberger
May 1974,
Endocrinology,
R W Hall, and
E Steinberger
January 1975,
Hormone research,
R W Hall, and
E Steinberger
July 1981,
Biochemical and biophysical research communications,
R W Hall, and
E Steinberger
December 1978,
Endocrinologia japonica,
R W Hall, and
E Steinberger
February 1984,
Neuroendocrinology,
R W Hall, and
E Steinberger
January 1974,
Neuroendocrinology,
R W Hall, and
E Steinberger
January 1976,
Endokrinologie,
R W Hall, and
E Steinberger
February 1980,
Brain research,
