Biomaterial Database

t(14;18) Translocations in Dioxin-Exposed Workers. 2022

Daniel Hryhorczuk, and Irina Dardynskaia, and Carsten Hirt, and Oleg Dardynskiy, and Wayman Turner, and Peter Ruestow, and Scott Bartell, and Kyle Steenland, and Oleksandr Zvinchuk, and Andrea A Baccarelli

Division of Environmental and Occupational Health Sciences, University of Illinois at Chicago School of Public Health, Chicago, Illinois (Dr Hryhorczuk, Dr Dardynskaia); Center for Global Health, University of Illinois College of Medicine, Chicago, Illinois (Dr Hryhorczuk, Dr Dardynskiy); Department of Internal Medicine C, Hematology and Oncology, Greifswald University, Greifswald, Germany (Dr Hirt); Environmental and Earth Sciences, Exponent, Atlanta, Georgia (Mr Turner); City of Chicago Department of Public Health, Chicago, Illinois (Dr Ruestow); Program in Public Health, University of California at Irvine, Irvine, California (Dr Bartell); Rollins School of Public Health, Emory University, Atlanta, Georgia (Dr Steenland); Institute of Pediatrics, Obstetrics and Gynecology, Kyiv, Ukraine (Dr Zvinchuk); Columbia University Mailman School of Public Health, New York, New York (Dr Baccarelli).

To determine if occupational exposure to dioxins is associated with an increased frequency of t(14;18) translocations. A cross-sectional analysis of serum dioxin levels and t(14;18) frequencies in peripheral blood mononuclear cells in 218 former chemical plant workers and 150 population controls. The workers had significantly higher geometric mean serum levels of 2,3,7,8-TCDD (26.2 vs 2.5 ppt) and TEQ (73.8 vs 17.7 ppt) than controls. There were no significant differences in the prevalence or frequency of t(14;18) translocations in the workers compared to controls. Among former workers with current or past chloracne who were t(14;18) positive, the frequency of translocations significantly increased with quartiles of 2,3,7,8-TCDD and TEQ. Chloracne appears to modulate the association between dioxin exposure and increased frequency of t(14;18) translocations.

UI	MeSH Term	Description	Entries
D007963	Leukocytes, Mononuclear	Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.	Mononuclear Leukocyte,Mononuclear Leukocytes,PBMC Peripheral Blood Mononuclear Cells,Peripheral Blood Human Mononuclear Cells,Peripheral Blood Mononuclear Cell,Peripheral Blood Mononuclear Cells,Leukocyte, Mononuclear
D003430	Cross-Sectional Studies	Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.	Disease Frequency Surveys,Prevalence Studies,Analysis, Cross-Sectional,Cross Sectional Analysis,Cross-Sectional Survey,Surveys, Disease Frequency,Analyses, Cross Sectional,Analyses, Cross-Sectional,Analysis, Cross Sectional,Cross Sectional Analyses,Cross Sectional Studies,Cross Sectional Survey,Cross-Sectional Analyses,Cross-Sectional Analysis,Cross-Sectional Study,Cross-Sectional Surveys,Disease Frequency Survey,Prevalence Study,Studies, Cross-Sectional,Studies, Prevalence,Study, Cross-Sectional,Study, Prevalence,Survey, Cross-Sectional,Survey, Disease Frequency,Surveys, Cross-Sectional
D004147	Dioxins	A family of compounds that contain the 1,4-dioxin structure. Many specific dioxin derivatives are listed as CARCINOGENS; TERATOGENS; or MUTAGENS.	Dioxin
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000072317	Polychlorinated Dibenzodioxins	Dibenzodioxin derivatives that contain multiple chloride atoms bound to the benzene ring structures.	TCDD,Tetrachlorodibenzodioxin,2,3,7,8-Tetrachlorodibenzo-p-dioxin,Chlorinated Dibenzo-p-dioxins,Dibenzo(b,e)(1,4)dioxin, 2,3,7,8-tetrachloro-,PCDD,Polychlorinated Dibenzo-p-dioxins,Polychlorinated Dibenzodioxin,Polychlorodibenzo-4-dioxin,Polychlorodibenzo-p-dioxin,Tetrachlorodibenzo-p-dioxin,Chlorinated Dibenzo p dioxins,Dibenzo-p-dioxins, Chlorinated,Dibenzo-p-dioxins, Polychlorinated,Dibenzodioxin, Polychlorinated,Dibenzodioxins, Polychlorinated,Polychlorinated Dibenzo p dioxins,Polychlorodibenzo 4 dioxin,Polychlorodibenzo p dioxin,Tetrachlorodibenzo p dioxin
D016273	Occupational Exposure	The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.	Exposure, Occupational,Exposures, Occupational,Occupational Exposures
D054506	Chloracne	ACNE-like skin eruptions caused by exposure to CHLORINE-containing compounds. Exposure can be by inhalation, ingestion, or through the skin. Chloracne is often seen in people who have occupational contact with chlorinated pesticides, wood preservatives, and sealants.	Chlorine Acne,Acne, Chlorine,Acnes, Chlorine,Chloracnes,Chlorine Acnes