BIOMAT Database Logo BIOMAT Database Logo

Polystyrene microplastics induced female reproductive toxicity in mice. 2022

Zhiqiang Liu, and Qingrui Zhuan, and Luyao Zhang, and Lin Meng, and Xiangwei Fu, and Yunpeng Hou
State Key Laboratories of Agrobiotechnology, College of Biological Sciences, China Agricultural University, No.2 Yuanmingyuan Xilu, Haidian District, Beijing 100193, PR China.

Plastics have caused serious environmental pollution. In recent years, microplastics (MPs) have caused widespread concern about their potential toxicity on animals and humans, especially on organ and tissue deposition. However, there is little known about the reproductive toxic effects of MPs in female mammals. In this study, the reproductive toxicity of polystyrene MPs (PS-MPs) in female mice was evaluated after continued exposure for 35 days. Results showed that PS-MPs could accumulate in heart, liver, spleen, lung, kidney, brain, large intestine, small intestine, uterus, ovary and blood of exposed mice. Moreover, PS-MPs exposure increased the IL-6 level and decreased malondialdehyde (MDA) level in mouse ovaries. The results also showed that PS-MPs exposure decreased the first polar body extrusion rate and the survival rate of superovulated oocytes. Meanwhile, PS-MPs reduced the level of glutathione (GSH), mitochondrial membrane potential (MMP), endoplasmic reticulum calcium ([Ca2+]ER) and increased reactive oxygen species (ROS) in oocytes. In conclusion, our study illustrated that PS-MPs exposure induced the inflammation of ovaries and reduced the quality of oocytes in mice, which provided a basis for studying the reproductive toxic mechanism of PS-MPs in female mammals.

UI MeSH Term Description Entries
D010969 Plastics Polymeric materials (usually organic) of large molecular weight which can be shaped by flow. Plastic usually refers to the final product with fillers, plasticizers, pigments, and stabilizers included (versus the resin, the homogeneous polymeric starting material). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Plastic
D011137 Polystyrenes Polymerized forms of styrene used as a biocompatible material, especially in dentistry. They are thermoplastic and are used as insulators, for injection molding and casting, as sheets, plates, rods, rigid forms and beads. Polystyrol,Polystyrene,Polystyrols
D012098 Reproduction The total process by which organisms produce offspring. (Stedman, 25th ed) Human Reproductive Index,Human Reproductive Indexes,Reproductive Period,Human Reproductive Indices,Index, Human Reproductive,Indexes, Human Reproductive,Indices, Human Reproductive,Period, Reproductive,Periods, Reproductive,Reproductive Index, Human,Reproductive Indices, Human,Reproductive Periods
D005260 Female Females
D000080545 Microplastics Plastic particles, less than 5 millimeters in diameter, that are generated from the degradation of larger pieces or are manufactured to be microstructures or smaller. Mesoplastics,Plastic Microparticles,Plastic Nanoparticles,Mesoplastic,Microparticle, Plastic,Microparticles, Plastic,Microplastic,Nanoparticle, Plastic,Nanoparticles, Plastic,Plastic Microparticle,Plastic Nanoparticle
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014874 Water Pollutants, Chemical Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water. Chemical Water Pollutants,Landfill Leachate,Leachate, Landfill,Pollutants, Chemical Water
D017382 Reactive Oxygen Species Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of SIGNAL TRANSDUCTION and GENE EXPRESSION, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS. Active Oxygen Species,Oxygen Radical,Oxygen Radicals,Pro-Oxidant,Reactive Oxygen Intermediates,Active Oxygen,Oxygen Species, Reactive,Pro-Oxidants,Oxygen, Active,Pro Oxidant,Pro Oxidants,Radical, Oxygen
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

Zhiqiang Liu, and Qingrui Zhuan, and Luyao Zhang, and Lin Meng, and Xiangwei Fu, and Yunpeng Hou
Polystyrene microplastics induced male reproductive toxicity in mice.
January 2021, Journal of hazardous materials,
Zhiqiang Liu, and Qingrui Zhuan, and Luyao Zhang, and Lin Meng, and Xiangwei Fu, and Yunpeng Hou
Probiotics improve polystyrene microplastics-induced male reproductive toxicity in mice by alleviating inflammatory response.
September 2023, Ecotoxicology and environmental safety,
Zhiqiang Liu, and Qingrui Zhuan, and Luyao Zhang, and Lin Meng, and Xiangwei Fu, and Yunpeng Hou
Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice.
March 2021, Journal of hazardous materials,
Zhiqiang Liu, and Qingrui Zhuan, and Luyao Zhang, and Lin Meng, and Xiangwei Fu, and Yunpeng Hou
Polystyrene microplastics induced male reproductive toxicity and transgenerational effects in freshwater prawn.
October 2022, The Science of the total environment,
Zhiqiang Liu, and Qingrui Zhuan, and Luyao Zhang, and Lin Meng, and Xiangwei Fu, and Yunpeng Hou
Co-exposure to polystyrene microplastics and microcystin-LR aggravated male reproductive toxicity in mice.
November 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Zhiqiang Liu, and Qingrui Zhuan, and Luyao Zhang, and Lin Meng, and Xiangwei Fu, and Yunpeng Hou
Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice.
December 2021, Reproductive toxicology (Elmsford, N.Y.),
Zhiqiang Liu, and Qingrui Zhuan, and Luyao Zhang, and Lin Meng, and Xiangwei Fu, and Yunpeng Hou
Polystyrene microplastics induce male reproductive toxicity in mice by activating spermatogonium mitochondrial oxidative stress and apoptosis.
May 2024, Chemico-biological interactions,
Zhiqiang Liu, and Qingrui Zhuan, and Luyao Zhang, and Lin Meng, and Xiangwei Fu, and Yunpeng Hou
Pulmonary Toxicity of Polystyrene, Polypropylene, and Polyvinyl Chloride Microplastics in Mice.
November 2022, Molecules (Basel, Switzerland),
Zhiqiang Liu, and Qingrui Zhuan, and Luyao Zhang, and Lin Meng, and Xiangwei Fu, and Yunpeng Hou
Reproductive toxicity on female mice induced by microcystin-LR.
January 2014, Environmental toxicology and pharmacology,
Zhiqiang Liu, and Qingrui Zhuan, and Luyao Zhang, and Lin Meng, and Xiangwei Fu, and Yunpeng Hou
Reproductive toxicity of UV-photodegraded polystyrene microplastics induced by DNA damage-dependent cell apoptosis in Caenorhabditis elegans.
March 2022, The Science of the total environment,
Copied contents to your clipboard!