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To determine whether human growth hormone (HGH) can cause proliferation of human leukemic lymphoblasts, we studied colony formation in semi-solid medium of MOLT 4, a cell line derived from an adolescent with acute lymphoblastic leukemia (ALL). Although exposure to single doses of HGH in supraphysiologic concentrations resulted in almost two-fold increases in number of colonies compared with control samples, physiologic concentrations had no effect. Similarly, physiologic concentrations of HGH had no effect on thymidine incorporation in short-term cultures of fresh lymphoblasts from children with ALL. In addition, total white blood cell and differential counts in 14 children with isolated growth hormone deficiency were reviewed pre- and post-treatment with HGH. In no case was there evidence of in vivo lymphocytosis or blastogenesis.
J Blatt, and
S Wenger, and
S Stitely, and
P A Lee
January 1986,
The Journal of clinical endocrinology and metabolism,
J Blatt, and
S Wenger, and
S Stitely, and
P A Lee
October 1973,
Experimental cell research,
J Blatt, and
S Wenger, and
S Stitely, and
P A Lee
February 1980,
Biochemical pharmacology,
J Blatt, and
S Wenger, and
S Stitely, and
P A Lee
January 1974,
Experimental hematology,
J Blatt, and
S Wenger, and
S Stitely, and
P A Lee
February 1976,
Lancet (London, England),
J Blatt, and
S Wenger, and
S Stitely, and
P A Lee
January 1988,
Leukemia research,
J Blatt, and
S Wenger, and
S Stitely, and
P A Lee
October 1993,
The Journal of biological chemistry,
J Blatt, and
S Wenger, and
S Stitely, and
P A Lee
December 1966,
Acta endocrinologica,
J Blatt, and
S Wenger, and
S Stitely, and
P A Lee
November 1979,
Experimental hematology,
J Blatt, and
S Wenger, and
S Stitely, and
P A Lee
October 1983,
Cancer treatment reports,
