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Serial samples of peripheral blood were obtained from 75 children with acute lymphoblastic leukemia in remission. An immunofluorescence assay was used to quantitate TdT-containing (terminal deoxynucleotidyl transferase-containing) cells in the mononuclear leukocyte fraction of these specimens. Nine relapses in 8 patients were preceded by elevations (0.12-0.70%) in peripheral blood terminal deoxynucleotidyl transferase-containing cells noted 1-33 weeks prior to relapse. No such elevations were observed prior to 6 relapses in 4 patients. Peripheral blood terminal transferase deoxynucleotidyl-containing cells were elevated (0.12-0.61%) in 22 children who did not relapse over a 5-82 week period of observation. The sensitivity (67%) and specificity (68%) of this assay are inadequate to establish which patients have minimal residual leukemia.
M L Hetherington, and
P R Huntsman, and
R G Smith, and
G R Buchanan
January 1987,
Leukemia research,
M L Hetherington, and
P R Huntsman, and
R G Smith, and
G R Buchanan
August 1993,
Leukemia,
M L Hetherington, and
P R Huntsman, and
R G Smith, and
G R Buchanan
June 1994,
Leukemia,
M L Hetherington, and
P R Huntsman, and
R G Smith, and
G R Buchanan
January 2000,
Archives of pathology & laboratory medicine,
M L Hetherington, and
P R Huntsman, and
R G Smith, and
G R Buchanan
August 1981,
Blood,
M L Hetherington, and
P R Huntsman, and
R G Smith, and
G R Buchanan
January 2017,
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society,
M L Hetherington, and
P R Huntsman, and
R G Smith, and
G R Buchanan
December 1978,
Blood,
M L Hetherington, and
P R Huntsman, and
R G Smith, and
G R Buchanan
January 1983,
Haematologica,
M L Hetherington, and
P R Huntsman, and
R G Smith, and
G R Buchanan
January 1987,
The International journal of biological markers,
M L Hetherington, and
P R Huntsman, and
R G Smith, and
G R Buchanan
April 2018,
Journal of pediatric hematology/oncology,
