BIOMAT Database Logo BIOMAT Database Logo

Tissue factor activity is increased in neutrophils from JAK2 V617F-mutated essential thrombocythemia and polycythemia vera patients. 2022

Brandi N Reeves, and Soo Jin Kim, and Jihyun Song, and Kathryn J Wilson, and Michael W Henderson, and Nigel S Key, and Rafal Pawlinski, and Josef T Prchal
Division of Hematology, Blood Research Center and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.

UI MeSH Term Description Entries
D009504 Neutrophils Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. LE Cells,Leukocytes, Polymorphonuclear,Polymorphonuclear Leukocytes,Polymorphonuclear Neutrophils,Neutrophil Band Cells,Band Cell, Neutrophil,Cell, LE,LE Cell,Leukocyte, Polymorphonuclear,Neutrophil,Neutrophil Band Cell,Neutrophil, Polymorphonuclear,Polymorphonuclear Leukocyte,Polymorphonuclear Neutrophil
D011087 Polycythemia Vera A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs. Erythremia,Osler-Vaquez Disease,Polycythemia Rubra Vera,Polycythemia Ruba Vera,Primary Polycythemia,Disease, Osler-Vaquez,Erythremias,Osler Vaquez Disease,Polycythemia Ruba Veras,Polycythemia Rubra Veras,Polycythemia, Primary,Polycythemias, Primary,Primary Polycythemias,Ruba Vera, Polycythemia,Ruba Veras, Polycythemia,Vera, Polycythemia Ruba,Vera, Polycythemia Rubra,Veras, Polycythemia Ruba,Veras, Polycythemia Rubra
D001777 Blood Coagulation The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot. Blood Clotting,Coagulation, Blood,Blood Clottings,Clotting, Blood
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013922 Thrombocytosis Increased numbers of platelets in the peripheral blood. (Dorland, 27th ed) Thrombocythemia,Thrombocythemias,Thrombocytoses
D013925 Thromboplastin Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation. Antigens, CD142,CD142 Antigens,Coagulation Factor III,Factor III,Tissue Factor,Tissue Thromboplastin,Blood Coagulation Factor III,Coagulin,Glomerular Procoagulant Activity,Prothrombinase,Tissue Factor Procoagulant,Urothromboplastin,Activity, Glomerular Procoagulant,Factor III, Coagulation,Procoagulant Activity, Glomerular,Procoagulant, Tissue Factor,Thromboplastin, Tissue
D015854 Up-Regulation A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. Receptor Up-Regulation,Upregulation,Up-Regulation (Physiology),Up Regulation
D017354 Point Mutation A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair. Mutation, Point,Mutations, Point,Point Mutations
D053614 Janus Kinase 2 A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS. JAK-2 Protein Tyrosine Kinase,JAK2 Protein Tyrosine Kinase,JAK 2 Protein Tyrosine Kinase

Related Publications

Brandi N Reeves, and Soo Jin Kim, and Jihyun Song, and Kathryn J Wilson, and Michael W Henderson, and Nigel S Key, and Rafal Pawlinski, and Josef T Prchal
Discriminating between essential thrombocythemia and masked polycythemia vera in JAK2 mutated patients.
June 2014, American journal of hematology,
Brandi N Reeves, and Soo Jin Kim, and Jihyun Song, and Kathryn J Wilson, and Michael W Henderson, and Nigel S Key, and Rafal Pawlinski, and Josef T Prchal
JAK2 V617F patients with essential thrombocythemia present with clinical features of polycythemia vera.
April 2008, Leukemia & lymphoma,
Brandi N Reeves, and Soo Jin Kim, and Jihyun Song, and Kathryn J Wilson, and Michael W Henderson, and Nigel S Key, and Rafal Pawlinski, and Josef T Prchal
Megakaryopoiesis and platelet function in polycythemia vera and essential thrombocythemia patients with JAK2 V617F mutation.
September 2008, International journal of hematology,
Brandi N Reeves, and Soo Jin Kim, and Jihyun Song, and Kathryn J Wilson, and Michael W Henderson, and Nigel S Key, and Rafal Pawlinski, and Josef T Prchal
The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera.
September 2006, Blood,
Brandi N Reeves, and Soo Jin Kim, and Jihyun Song, and Kathryn J Wilson, and Michael W Henderson, and Nigel S Key, and Rafal Pawlinski, and Josef T Prchal
Iron deficiency in JAK2 exon12 and JAK2-V617F mutated polycythemia vera.
September 2021, Blood cancer journal,
Brandi N Reeves, and Soo Jin Kim, and Jihyun Song, and Kathryn J Wilson, and Michael W Henderson, and Nigel S Key, and Rafal Pawlinski, and Josef T Prchal
Sigmoid Venous Thrombosis in JAK2 V617F Mutated Polycythemia Vera.
January 2022, Case reports in hematology,
Brandi N Reeves, and Soo Jin Kim, and Jihyun Song, and Kathryn J Wilson, and Michael W Henderson, and Nigel S Key, and Rafal Pawlinski, and Josef T Prchal
Evaluation of the JAK2-V617F gene mutation in Turkish patients with essential thrombocythemia and polycythemia vera.
September 2012, Molecular biology reports,
Brandi N Reeves, and Soo Jin Kim, and Jihyun Song, and Kathryn J Wilson, and Michael W Henderson, and Nigel S Key, and Rafal Pawlinski, and Josef T Prchal
Clinical features and outcomes of JAK2 V617F-positive polycythemia vera and essential thrombocythemia according to the JAK2 V617F allele burden.
December 2021, Blood research,
Brandi N Reeves, and Soo Jin Kim, and Jihyun Song, and Kathryn J Wilson, and Michael W Henderson, and Nigel S Key, and Rafal Pawlinski, and Josef T Prchal
A higher JAK2 V617F-mutated clone is observed in platelets than in granulocytes from essential thrombocythemia patients, but not in patients with polycythemia vera and primary myelofibrosis.
June 2007, Leukemia,
Brandi N Reeves, and Soo Jin Kim, and Jihyun Song, and Kathryn J Wilson, and Michael W Henderson, and Nigel S Key, and Rafal Pawlinski, and Josef T Prchal
Risk of thrombosis in patients with essential thrombocythemia and polycythemia vera according to JAK2 V617F mutation status.
January 2007, Haematologica,
Copied contents to your clipboard!