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Glycyrrhizin (GL), one of the plant extracts, was investigated for its antiviral action on the human immunodeficiency virus [HIV (HTLV-III/LAV)] in vitro, using cytopathic effect and plaque forming assay system in MT-4 cells (a HTLV-I-carrying cell line). Cloned Molt-4 cells (clone No. 8), which are sensitive to HIV and fuse to giant cells after infection, were also used as a parameter for cytopathic effect of HIV. GL completely inhibited HIV-induced plaque formation in MT-4 cells at a concentration of 0.6 mM, the 50% inhibitory dose being 0.15 mM. GL completely inhibited the cytopathic effect of HIV and the HIV-specific antigen expression in MT-4 cells at a concentration of 0.3 and 0.6 mM, respectively. Furthermore, GL inhibited giant cell formation of HIV-infected Molt-4 clone No. 8 cells. GL had no direct effect on the reverse transcriptase of HIV. Its mechanism of anti-HIV action remains to be elucidated.
M Ito, and
H Nakashima, and
M Baba, and
R Pauwels, and
E De Clercq, and
S Shigeta, and
N Yamamoto
January 1987,
Postepy biochemii,
M Ito, and
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M Baba, and
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E De Clercq, and
S Shigeta, and
N Yamamoto
March 1986,
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M Ito, and
H Nakashima, and
M Baba, and
R Pauwels, and
E De Clercq, and
S Shigeta, and
N Yamamoto
January 1986,
Infection,
M Ito, and
H Nakashima, and
M Baba, and
R Pauwels, and
E De Clercq, and
S Shigeta, and
N Yamamoto
November 1988,
The Journal of antibiotics,
M Ito, and
H Nakashima, and
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N Yamamoto
January 1984,
Princess Takamatsu symposia,
M Ito, and
H Nakashima, and
M Baba, and
R Pauwels, and
E De Clercq, and
S Shigeta, and
N Yamamoto
August 1987,
Die Quintessenz,
M Ito, and
H Nakashima, and
M Baba, and
R Pauwels, and
E De Clercq, and
S Shigeta, and
N Yamamoto
October 1984,
Science (New York, N.Y.),
M Ito, and
H Nakashima, and
M Baba, and
R Pauwels, and
E De Clercq, and
S Shigeta, and
N Yamamoto
February 1988,
Journal of medicinal chemistry,
M Ito, and
H Nakashima, and
M Baba, and
R Pauwels, and
E De Clercq, and
S Shigeta, and
N Yamamoto
March 1986,
International journal of cancer,
M Ito, and
H Nakashima, and
M Baba, and
R Pauwels, and
E De Clercq, and
S Shigeta, and
N Yamamoto
June 1987,
Antimicrobial agents and chemotherapy,
