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A blinded cooperative assay of several androstane and pregnane steroid metabolites has been carried out in order to determine whether 5beta-H derivatives are as active as testosterone in stimulating in vivo erythropoiesis. The steroids tested were: testosterone, 5alpha-dihydrotestosterone, 5beta-dihydrotestosterone, 5beta-pregnane-3,20-dione, 3alpha-dihydroxy-5beta-pregnane-11,20-dione and 3beta-hydroxy-5beta-pregnan-20-one. The incorporation of radioactive iron into newly formed red cells in exhypoxic polycythemic mice was used to compare the effects of the steroids. Testosterone and 5alpha-dihydrotestosterone both produced significant increases in 59Fe incorporation. 5beta-dihydrotestosterone, 5beta-pregnane-3,20-dione, 3alpha-hydroxy-5beta-pregnane-11,20-dione and 3beta-hydroxy-5beta-pregnan-20-one were all devoid of significant erythropoietic activity in polycythemic mice in almost all instances. Thus, under the conditions chosen, this study failed to demonstrate that 5beta-steroids increase radioactive iron incorporation in red cells of exhypoxic polycythemic mice.
J W Fisher, and
J W Adamson, and
J F Camiscoli, and
W Fried, and
A S Gordon, and
J Schooley, and
E Zanjani
March 1970,
Proceedings of the National Academy of Sciences of the United States of America,
J W Fisher, and
J W Adamson, and
J F Camiscoli, and
W Fried, and
A S Gordon, and
J Schooley, and
E Zanjani
May 1970,
American journal of veterinary research,
J W Fisher, and
J W Adamson, and
J F Camiscoli, and
W Fried, and
A S Gordon, and
J Schooley, and
E Zanjani
January 1968,
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J W Fisher, and
J W Adamson, and
J F Camiscoli, and
W Fried, and
A S Gordon, and
J Schooley, and
E Zanjani
June 1966,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J W Fisher, and
J W Adamson, and
J F Camiscoli, and
W Fried, and
A S Gordon, and
J Schooley, and
E Zanjani
January 1973,
Experimental hematology,
J W Fisher, and
J W Adamson, and
J F Camiscoli, and
W Fried, and
A S Gordon, and
J Schooley, and
E Zanjani
January 1957,
Transactions of the Association of American Physicians,
J W Fisher, and
J W Adamson, and
J F Camiscoli, and
W Fried, and
A S Gordon, and
J Schooley, and
E Zanjani
December 1964,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J W Fisher, and
J W Adamson, and
J F Camiscoli, and
W Fried, and
A S Gordon, and
J Schooley, and
E Zanjani
January 1972,
Acta physiologica latino americana,
J W Fisher, and
J W Adamson, and
J F Camiscoli, and
W Fried, and
A S Gordon, and
J Schooley, and
E Zanjani
January 1973,
Transactions of the Association of American Physicians,
J W Fisher, and
J W Adamson, and
J F Camiscoli, and
W Fried, and
A S Gordon, and
J Schooley, and
E Zanjani
January 1972,
The American journal of physiology,
