Biomaterial Database

The effects of indomethacin on resorption and ankylosis in replanted teeth. 1987

J S Walsh, and M R Fey, and L M Omnell

Indomethacin, a nonsteroidal, antiinflammatory analgesic, interferes with the action of prostaglandin synthetase such that osteoclastic activity is reduced. Encouraging results were obtained, pointing toward an improved long-term prognosis for replanted teeth, and as a possible solution to excessive root resorption.

UI	MeSH Term	Description	Entries
D007213	Indomethacin	A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.	Amuno,Indocid,Indocin,Indomet 140,Indometacin,Indomethacin Hydrochloride,Metindol,Osmosin
D011379	Prognosis	A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.	Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000844	Ankylosis	Fixation and immobility of a joint.	Ankyloses
D012391	Root Resorption	Resorption in which cementum or dentin is lost from the root of a tooth owing to cementoclastic or osteoclastic activity in conditions such as trauma of occlusion or neoplasms. (Dorland, 27th ed)	Resorption, Root,Resorptions, Root,Root Resorptions
D014076	Tooth Diseases	Diseases involving the TEETH.	Disease, Tooth,Diseases, Tooth,Tooth Disease
D014090	Tooth Replantation	Reinsertion of a tooth into the alveolus from which it was removed or otherwise lost.	Reimplantation, Tooth,Replantation, Tooth,Tooth Reimplantation,Reimplantations, Tooth,Replantations, Tooth,Tooth Reimplantations,Tooth Replantations
D014092	Tooth Root	The part of a tooth from the neck to the apex, embedded in the alveolar process and covered with cementum. A root may be single or divided into several branches, usually identified by their relative position, e.g., lingual root or buccal root. Single-rooted teeth include mandibular first and second premolars and the maxillary second premolar teeth. The maxillary first premolar has two roots in most cases. Maxillary molars have three roots. (Jablonski, Dictionary of Dentistry, 1992, p690)	Root, Tooth,Roots, Tooth,Tooth Roots