Pediatric T-wave memory after accessory pathway ablation in Wolff-Parkinson-White syndrome. 2022

Karyn M Austin, and Mark E Alexander, and John K Triedman
Arrhythmia Service, Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts. Electronic address: karyn.austin@cardio.chboston.org.

Altered ventricular depolarization due to manifest accessory pathway conduction (ie, Wolff-Parkinson-White syndrome) leads to repolarization abnormalities that persist after pathway ablation. The term T-wave memory (TWM) has been applied to these changes, as the postablation T-wave vector "remembers" the pre-excited QRS vector. In adults, these abnormalities can be misinterpreted as ischemia leading to unnecessary interventions. To date, no comprehensive studies have evaluated this phenomenon in the pediatric population. The purpose of this study was to define TWM in the pediatric population, identify preablation risk factors, and delineate the timeline of recovery. Pre- and postablation electrocardiograms (ECGs) in patients ≤25 years were analyzed over a 5-year period. Frontal plane QTc interval, T-wave axis, QRST angle, and T-wave inversions were used to identify patients with TWM. Univariate analysis was performed to determine the association of preablation ECG features with the outcome of TWM. TWM was present in 42% of pediatric patients, with resolution occurring within 3 months of ablation. Preablation QRS axis <0° was a strong predictor of TWM (odds ratio [OR] 15.2; 95% confidence interval [CI] 5.7-40), followed by posteroseptal pathway location (right posteroseptal-OR 8.9; 95% CI 4.2-18.8; left posteroseptal-OR 6.1; 95% CI 1.7-22.3). The degree of pre-excitation had a modest association with the development of TWM. No adverse events were observed. TWM is less common in children compared to adults, and normalization occurred within 3 months postablation. The most predictive features for the development of TWM include a leftward pre-excited QRS axis and posteroseptal pathway location.

UI MeSH Term Description Entries
D011226 Pre-Excitation Syndromes A group of conditions in which HEART VENTRICLE activation by the atrial impulse is faster than the normal impulse conduction from the SINOATRIAL NODE. In these pre-excitation syndromes, atrial impulses often bypass the ATRIOVENTRICULAR NODE delay and travel via ACCESSORY CONDUCTING PATHWAYS connecting the atrium directly to the BUNDLE OF HIS. Preexcitation Syndrome,Pre Excitation Syndromes,Pre-Excitation Syndrome,Preexcitation Syndromes
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D004562 Electrocardiography Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY. 12-Lead ECG,12-Lead EKG,12-Lead Electrocardiography,Cardiography,ECG,EKG,Electrocardiogram,Electrocardiograph,12 Lead ECG,12 Lead EKG,12 Lead Electrocardiography,12-Lead ECGs,12-Lead EKGs,12-Lead Electrocardiographies,Cardiographies,ECG, 12-Lead,EKG, 12-Lead,Electrocardiograms,Electrocardiographies, 12-Lead,Electrocardiographs,Electrocardiography, 12-Lead
D006329 Heart Conduction System An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart. Conduction System, Heart,Conduction Systems, Heart,Heart Conduction Systems,System, Heart Conduction,Systems, Heart Conduction
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D014927 Wolff-Parkinson-White Syndrome A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase. WPW Syndrome,Anomalous Ventricular Excitation Syndrome,Auriculoventricular Accessory Pathway Syndrome,False Bundle-Branch Block Syndrome,Ventricular Pre-Excitation with Arrhythmia,Wolf-Parkinson-White Syndrome,Syndrome, WPW,Syndrome, Wolf-Parkinson-White,Syndrome, Wolff-Parkinson-White,Wolf Parkinson White Syndrome,Wolff Parkinson White Syndrome
D017115 Catheter Ablation Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias. Ablation, Transvenous Electric,Catheter Ablation, Electric,Catheter Ablation, Percutaneous,Catheter Ablation, Radiofrequency,Catheter Ablation, Transvenous,Ablation, Catheter,Ablation, Transvenous Electrical,Catheter Ablation, Electrical,Electric Catheter Ablation,Electrical Catheter Ablation,Percutaneous Catheter Ablation,Radiofrequency Catheter Ablation,Transvenous Catheter Ablation,Ablation, Electric Catheter,Ablation, Electrical Catheter,Ablation, Percutaneous Catheter,Ablation, Radiofrequency Catheter,Ablation, Transvenous Catheter,Electric Ablation, Transvenous,Electrical Ablation, Transvenous,Transvenous Electric Ablation,Transvenous Electrical Ablation
D058606 Accessory Atrioventricular Bundle Extra impulse-conducting tissue in the heart that creates abnormal impulse-conducting connections between HEART ATRIA and HEART VENTRICLES. Bundle of Kent,Mahaim Fiber,Accessory Atrioventricular Pathway,Accessory Atrioventricular Pathways,Accessory Conducting Pathway,Accessory Conducting Pathways,Atrio-Hisian Bypass Tract,Atriohisian Fibers,Atriohisian Tract,Concealed Accessory Pathway,Fasciculoventricular Accessory Pathway,Fasciculoventricular Pathway,James Fibers,Kent Bundle,Mahaim Fibers,Nodoventricular Accessory Pathway,Nodoventricular Pathway,Accessory Atrioventricular Bundles,Accessory Pathway, Concealed,Accessory Pathway, Fasciculoventricular,Accessory Pathway, Nodoventricular,Accessory Pathways, Concealed,Accessory Pathways, Fasciculoventricular,Accessory Pathways, Nodoventricular,Atrio Hisian Bypass Tract,Atrio-Hisian Bypass Tracts,Atriohisian Fiber,Atriohisian Tracts,Atrioventricular Bundle, Accessory,Atrioventricular Bundles, Accessory,Atrioventricular Pathway, Accessory,Atrioventricular Pathways, Accessory,Bundle, Accessory Atrioventricular,Bundle, Kent,Bundles, Accessory Atrioventricular,Bypass Tract, Atrio-Hisian,Bypass Tracts, Atrio-Hisian,Concealed Accessory Pathways,Conducting Pathway, Accessory,Conducting Pathways, Accessory,Fasciculoventricular Accessory Pathways,Fasciculoventricular Pathways,Fiber, Atriohisian,Fiber, Mahaim,Fibers, Atriohisian,Fibers, James,Fibers, Mahaim,Nodoventricular Accessory Pathways,Nodoventricular Pathways,Pathway, Accessory Atrioventricular,Pathway, Accessory Conducting,Pathway, Concealed Accessory,Pathway, Fasciculoventricular,Pathway, Fasciculoventricular Accessory,Pathway, Nodoventricular,Pathway, Nodoventricular Accessory,Pathways, Accessory Atrioventricular,Pathways, Accessory Conducting,Pathways, Concealed Accessory,Pathways, Fasciculoventricular,Pathways, Fasciculoventricular Accessory,Pathways, Nodoventricular,Pathways, Nodoventricular Accessory,Tract, Atrio-Hisian Bypass,Tract, Atriohisian,Tracts, Atrio-Hisian Bypass,Tracts, Atriohisian

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