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Promyelocytic blast crisis of Philadelphia-positive thrombocythemia with translocations (9;22) and (15;17). 1987
J L Laï, and
P Fenaux, and
M Zandecki, and
J B Savary, and
M H Estienne, and
J P Jouet, and
F Bauters, and
M Deminatti
Service de Génétique, Faculté de Médecine, Hôpital Calmette, Lille, France.
We report a promyelocytic blast crisis in a case of Ph-positive thrombocythemia with both t(9;22) and t(15;17). Our patient confirms the specificity of t(15;17) in malignant proliferation of promyelocytes and suggests its appearance as a second genetic event in the genesis of blast crisis occurring in a Ph-positive clone.
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