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Plasma and red blood cells (RBCs), amitriptyline, nortriptyline, imipramine, desipramine, doxepin, and desmethyl doxepin levels were measured in depressed inpatients during steady-state kinetics. A strong positive correlation between the drug levels in plasma and RBCs was found for amitriptyline, nortriptyline, desipramine, and desmethyl doxepin. However, at a given plasma level, up to a 6-fold interindividual variation in the RBC drug levels was found. The correlations between plasma and RBC imipramine and doxepin levels were low. The interindividual variation in the RBC-plasma tricyclic level ratios was large enough to warrant further clinical studies on the relationship between efficacy and pharmacokinetics of tricyclic antidepressants.
M Linnoila, and
F Dorrity, and
K Jobson
July 1974,
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M Linnoila, and
F Dorrity, and
K Jobson
January 1977,
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M Linnoila, and
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K Jobson
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M Linnoila, and
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K Jobson
June 1979,
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M Linnoila, and
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March 1990,
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M Linnoila, and
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M Linnoila, and
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M Linnoila, and
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September 1990,
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M Linnoila, and
F Dorrity, and
K Jobson
January 1983,
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M Linnoila, and
F Dorrity, and
K Jobson
October 1976,
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