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The three Hodgkin disease-derived cell lines L 428, L 540, and L 591 were characterized in their carbohydrate epitope composition by a panel of lectins. Nine other human cell lines were tested in comparison to the Hodgkin (H) and Sternberg Reed (SR) cells: promyelocytic (HL 60), lymphoblastoid, myeloma, histiocytic lymphoma (U 937), and other non-Hodgkin lymphoma cell lines. Twenty-four different fluoresceinated lectins bound to the Hodgkin and other cell lines in different percentages of positive cells and with varying intensities. Lotus lectin and a monoclonal anti-Lewis blood group X antibody showed very similar binding patterns (L 428, L 540, HL 60, U 937). Soybean agglutinin stained only L 428 and L 540, although nearly all were positive after neuraminidase treatment. Cell lysis of the three H cell lines resulted in a very similar electrophoretic mobility pattern of proteins. In addition, staining of transblotted glycoproteins with biotinylated concanavalin A by avidin peroxidase reaction revealed corresponding bands. Differences were seen with Lotus staining. In summary, the origin of H cells is still unknown, but there is obviously some relationship in the glycoconjugate profile to the myelohistiocytic lineage.
M Schwonzen, and
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June 2001,
Melanoma research,
M Schwonzen, and
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January 1988,
Anticancer research,
M Schwonzen, and
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H Burrichter, and
V Diehl
September 1984,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
M Schwonzen, and
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V Diehl
September 1984,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
M Schwonzen, and
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January 1989,
Cancer treatment and research,
M Schwonzen, and
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February 2021,
Biomedicines,
M Schwonzen, and
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M Schaadt, and
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V Diehl
July 2009,
Leukemia research,
M Schwonzen, and
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V Diehl
August 1992,
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft,
M Schwonzen, and
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November 1994,
The Histochemical journal,
M Schwonzen, and
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V Diehl
February 1993,
International journal of pancreatology : official journal of the International Association of Pancreatology,
