BIOMAT Database Logo BIOMAT Database Logo

Lactobacillus rhamnosus GG Colonization in Early Life Ameliorates Inflammaging of Offspring by Activating SIRT1/AMPK/PGC-1α Pathway. 2021

Tianyu Liu, and Xueli Song, and Yaping An, and Xuemei Wu, and Wanru Zhang, and Jia Li, and Yue Sun, and Ge Jin, and Xiang Liu, and Zixuan Guo, and Bangmao Wang, and Ping Lei, and Hailong Cao
Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.

Inflammaging refers to chronic, low-grade inflammation during aging, which contributes to the pathogenesis of age-related diseases. Studies have shown that probiotic intervention in the aging stage could delay aging-related disorders. However, whether the application of probiotics in early life could have antiaging effects on offspring was unknown. Here, we investigated the effects of Lactobacillus rhamnosus GG (LGG) colonization in early life on inflammaging of offspring. Pregnant mice with the same conception time were given LGG live bacteria (LC group) or LGG fixed bacteria (NC group) from the 18th day after pregnancy until natural birth. The progeny mice were treated with 107 cfu of live or fixed LGG for 0-5 days after birth, respectively. LGG colonization could be detected in the feces of 3-week offspring. The 16S rRNA sequencing analysis of 3-week-old offspring showed that colonization of LGG in early life could alter the composition and diversity of gut microbiota. Interestingly, the beneficial effects of LGG colonization in early life on the microbiota lasted to 8 months old. The abundance of longevity-related bacteria (Lactobacillus, Bifidobacterium, and Akkermansia muciniphila) increased significantly in the LGG colonization group. In addition, LGG colonization increased the abundance of short-chain fatty acid- (SCFA-) producing bacteria and the production of cecal SCFAs. LGG colonization in early life protected the intestinal barrier, enhanced antioxidant defense, attenuated epithelial cell DNA damage, and inhibited intestinal low-grade inflammation in 8-month-old progeny mice. Mechanically, LGG could upregulate Sirtuin1 (SIRT1)/Adenosine 5'-monophosphate-activated protein kinase (AMPK)/Peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) pathway and repress activation of nuclear factor-kappa B (NF-κB), while the protective effect of LGG was blunted after SIRT1 gene silencing. Together, LGG colonization in early life could ameliorate inflammaging of offspring, which would provide a new strategy for the prevention of age-related diseases.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D007422 Intestines The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE. Intestine
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D000069196 Gastrointestinal Microbiome All of the microbial organisms that naturally exist within the GASTROINTESTINAL TRACT. Enteric Bacteria,Gastric Microbiome,Gastrointestinal Flora,Gastrointestinal Microbial Community,Gastrointestinal Microbiota,Gastrointestinal Microflora,Gut Flora,Gut Microbiome,Gut Microbiota,Gut Microflora,Intestinal Flora,Intestinal Microbiome,Intestinal Microbiota,Intestinal Microflora,Bacteria, Enteric,Flora, Gastrointestinal,Flora, Gut,Flora, Intestinal,Gastric Microbiomes,Gastrointestinal Microbial Communities,Gastrointestinal Microbiomes,Gastrointestinal Microbiotas,Gut Microbiomes,Gut Microbiotas,Intestinal Microbiomes,Intestinal Microbiotas,Microbial Community, Gastrointestinal,Microbiome, Gastric,Microbiome, Gastrointestinal,Microbiome, Gut,Microbiome, Intestinal,Microbiota, Gastrointestinal,Microbiota, Gut,Microbiota, Intestinal,Microflora, Gastrointestinal,Microflora, Gut,Microflora, Intestinal
D000071248 Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM. PGC-1-alpha Protein,PPARGC-1-alpha Protein,PPARGC1a Protein,PGC 1 alpha Protein,PPARGC 1 alpha Protein,Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 alpha
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Tianyu Liu, and Xueli Song, and Yaping An, and Xuemei Wu, and Wanru Zhang, and Jia Li, and Yue Sun, and Ge Jin, and Xiang Liu, and Zixuan Guo, and Bangmao Wang, and Ping Lei, and Hailong Cao
Acacetin ameliorates cardiac hypertrophy by activating Sirt1/AMPK/PGC-1α pathway.
April 2022, European journal of pharmacology,
Tianyu Liu, and Xueli Song, and Yaping An, and Xuemei Wu, and Wanru Zhang, and Jia Li, and Yue Sun, and Ge Jin, and Xiang Liu, and Zixuan Guo, and Bangmao Wang, and Ping Lei, and Hailong Cao
IL-10 ameliorates PM2.5-induced lung injury by activating the AMPK/SIRT1/PGC-1α pathway.
August 2021, Environmental toxicology and pharmacology,
Tianyu Liu, and Xueli Song, and Yaping An, and Xuemei Wu, and Wanru Zhang, and Jia Li, and Yue Sun, and Ge Jin, and Xiang Liu, and Zixuan Guo, and Bangmao Wang, and Ping Lei, and Hailong Cao
Ameliorative effect of Lactobacillus rhamnosus GG on acetaminophen-induced hepatotoxicity via PKC/Nrf2/PGC-1α pathway.
October 2022, Journal, genetic engineering & biotechnology,
Tianyu Liu, and Xueli Song, and Yaping An, and Xuemei Wu, and Wanru Zhang, and Jia Li, and Yue Sun, and Ge Jin, and Xiang Liu, and Zixuan Guo, and Bangmao Wang, and Ping Lei, and Hailong Cao
Vaginal colonization by orally administered Lactobacillus rhamnosus GG.
November 2003, The Israel Medical Association journal : IMAJ,
Tianyu Liu, and Xueli Song, and Yaping An, and Xuemei Wu, and Wanru Zhang, and Jia Li, and Yue Sun, and Ge Jin, and Xiang Liu, and Zixuan Guo, and Bangmao Wang, and Ping Lei, and Hailong Cao
D-allulose ameliorates adiposity through the AMPK-SIRT1-PGC-1α pathway in HFD-induced SD rats.
January 2021, Food & nutrition research,
Tianyu Liu, and Xueli Song, and Yaping An, and Xuemei Wu, and Wanru Zhang, and Jia Li, and Yue Sun, and Ge Jin, and Xiang Liu, and Zixuan Guo, and Bangmao Wang, and Ping Lei, and Hailong Cao
Colonization of Lactobacillus rhamnosus GG in the oral cavity.
April 2006, Oral microbiology and immunology,
Tianyu Liu, and Xueli Song, and Yaping An, and Xuemei Wu, and Wanru Zhang, and Jia Li, and Yue Sun, and Ge Jin, and Xiang Liu, and Zixuan Guo, and Bangmao Wang, and Ping Lei, and Hailong Cao
Empagliflozin ameliorates diabetic cardiomyopathy probably via activating AMPK/PGC-1α and inhibiting the RhoA/ROCK pathway.
December 2023, World journal of diabetes,
Tianyu Liu, and Xueli Song, and Yaping An, and Xuemei Wu, and Wanru Zhang, and Jia Li, and Yue Sun, and Ge Jin, and Xiang Liu, and Zixuan Guo, and Bangmao Wang, and Ping Lei, and Hailong Cao
Early life Lactobacillus rhamnosus GG colonisation inhibits intestinal tumour formation.
June 2022, British journal of cancer,
Tianyu Liu, and Xueli Song, and Yaping An, and Xuemei Wu, and Wanru Zhang, and Jia Li, and Yue Sun, and Ge Jin, and Xiang Liu, and Zixuan Guo, and Bangmao Wang, and Ping Lei, and Hailong Cao
Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model.
March 2024, NPJ biofilms and microbiomes,
Tianyu Liu, and Xueli Song, and Yaping An, and Xuemei Wu, and Wanru Zhang, and Jia Li, and Yue Sun, and Ge Jin, and Xiang Liu, and Zixuan Guo, and Bangmao Wang, and Ping Lei, and Hailong Cao
Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway.
April 2016, Scientific reports,
Copied contents to your clipboard!