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Risk of N-Nitrosodimethylamine (NMDA) Formation With Ranitidine.
2021
David G Strauss, and Jeffry Florian, and David Keire
Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
Associated MeSH Terms
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MeSH Term
Description
Entries
D011899
Ranitidine
A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
AH-19065,Biotidin,N (2-(((5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine,Ranisen,Ranitidin,Ranitidine Hydrochloride,Sostril,Zantac,Zantic,AH 19065,AH19065,Hydrochloride, Ranitidine
D004128
Dimethylnitrosamine
A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.
Nitrosodimethylamine,N-Nitrosodimethylamine,NDMA Nitrosodimethylamine,N Nitrosodimethylamine,Nitrosodimethylamine, NDMA
D014874
Water Pollutants, Chemical
Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.
Chemical Water Pollutants,Landfill Leachate,Leachate, Landfill,Pollutants, Chemical Water
Related Publications
David G Strauss, and Jeffry Florian, and David Keire
Risk of N-Nitrosodimethylamine (NMDA) Formation With Ranitidine-Reply.
November 2021, JAMA,
David G Strauss, and Jeffry Florian, and David Keire
Ranitidine and Risk of N-Nitrosodimethylamine (NDMA) Formation.
July 2021, JAMA,
David G Strauss, and Jeffry Florian, and David Keire
Characterization of N-nitrosodimethylamine formation from the ozonation of ranitidine.
August 2017, Journal of environmental sciences (China),
David G Strauss, and Jeffry Florian, and David Keire
Role of ranitidine in N-nitrosodimethylamine formation during chloramination of competing micropollutants.
February 2021, The Science of the total environment,
David G Strauss, and Jeffry Florian, and David Keire
Nitrite ion mitigates the formation of N-nitrosodimethylamine (NDMA) during chloramination of ranitidine.
August 2018, The Science of the total environment,
David G Strauss, and Jeffry Florian, and David Keire
N-Nitrosodimethylamine (NDMA) Formation from Ranitidine Impurities: Possible Root Causes of the Presence of NDMA in Ranitidine Hydrochloride.
January 2021, Chemical & pharmaceutical bulletin,
David G Strauss, and Jeffry Florian, and David Keire
Temperature-Dependent Formation of N-Nitrosodimethylamine during the Storage of Ranitidine Reagent Powders and Tablets.
October 2020, Chemical & pharmaceutical bulletin,
David G Strauss, and Jeffry Florian, and David Keire
Reduction of N-nitrosodimethylamine formation from ranitidine by ozonation preceding chloramination: influencing factors and mechanisms.
May 2018, Environmental science and pollution research international,
David G Strauss, and Jeffry Florian, and David Keire
Oral intake of ranitidine increases urinary excretion of N-nitrosodimethylamine.
June 2016, Carcinogenesis,
David G Strauss, and Jeffry Florian, and David Keire
Analysis of Ranitidine-Associated N-Nitrosodimethylamine Production Under Simulated Physiologic Conditions.
January 2021, JAMA network open,
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