This study reports on pressures recorded at the denture base-mucosal surface interface in four edentulous subjects. Four sites were selected, namely (a) the midpalatal region in the upper complete denture, (b) the labial to the mid-line lower complete denture, (c) directly under the lower left and (d) right first molar teeth. The study examined the reproducibility of the pressure values obtained when the subjects chewed two test foods (carrot and peanut). The subjects repeated the chewing sequences on the same day and one subject was tested over a 3-day period. The younger subjects and subjects with the shortest chewing sequences gave the most reproducible results. The two foods were shown to have different effects both on the pressure values recorded and the duration of the chewing sequence. Patients who transferred the food bolus from side to side during the chewing sequence affected the reproducibility of the results obtained from the lower denture transducers.