Synthesis by gamma irradiation of hyaluronic acid-polyvinyl alcohol hydrogel for biomedical applications. 2021

Fernanda Kamila Godoy-Alvarez, and Maykel González-Torres, and David M Giraldo-Gomez, and Roberto Sánchez-Sánchez, and Mario A Pérez-Dí Az, and Manuel González-Del Carmen, and Gabriela Figueroa-González, and Octavio D Reyes-Hernández, and Javad Sharifi-Rad, and Hernán Cortés, and Marí A Luisa Del Prado-Audelo, and Gerardo Leyva-Gómez
Departamento de Farmacia, Facultad de Quí-mica, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico. luisa.delpradoa@gmail.com.

Hyaluronic acid (HA) is one of the most attractive natural polymers employed in biomaterials with biological applications. This polysaccharide is found in different tissues of the body because it is a natural component of the extracellular matrix; furthermore, it has crucial functions in cell growth, migration, and differentiation. Since its biological characteristics, HA has been utilized for the new biomaterial's development for tissue engineering, such as hydrogels. These hydrophilic macromolecular networks have gained significant attention due to their unique properties, making them potential candidates to be applied in biomedical fields. Different mechanisms to obtain hydrogels have been described. However, the research of new non-toxic methods has been growing in recent years. In this study, we prepared a new hydrogel of HA and polyvinyl alcohol by the cost-effective technique of cross-linking by gamma irradiation. The hydrogel was elaborated for the first time and was characterized by several methods such as Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry, Thermogravimetric Analysis, and Scanning Electron Microscopy. Likewise, we evaluated the cytotoxicity of the biomaterial and its influence on cell migration in human fibroblasts. Furthermore, we provide preliminary evidence of the wound closure effect in a cellular wound model. The novel hydrogel offers an increase of HA stability with the potential to expand the useful life of HA in its different medical applications.

UI MeSH Term Description Entries
D008855 Microscopy, Electron, Scanning Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY. Scanning Electron Microscopy,Electron Scanning Microscopy,Electron Microscopies, Scanning,Electron Microscopy, Scanning,Electron Scanning Microscopies,Microscopies, Electron Scanning,Microscopies, Scanning Electron,Microscopy, Electron Scanning,Microscopy, Scanning Electron,Scanning Electron Microscopies,Scanning Microscopies, Electron,Scanning Microscopy, Electron
D008956 Models, Chemical Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment. Chemical Models,Chemical Model,Model, Chemical
D011108 Polymers Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS). Polymer
D011142 Polyvinyl Alcohol A polymer prepared from polyvinyl acetates by replacement of the acetate groups with hydroxyl groups. It is used as a pharmaceutic aid and ophthalmic lubricant as well as in the manufacture of surface coatings artificial sponges, cosmetics, and other products. Liquifilm Tears,Polyviol,Alcohol, Polyvinyl,Tears, Liquifilm
D002465 Cell Movement The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell. Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D005347 Fibroblasts Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. Fibroblast
D005720 Gamma Rays Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source. Gamma Wave,Gamma Radiation,Nuclear X-Rays,Radiation, Gamma,X-Rays, Nuclear,Gamma Radiations,Gamma Ray,Gamma Waves,Nuclear X Rays,Nuclear X-Ray,Ray, Gamma,Wave, Gamma,Waves, Gamma,X Rays, Nuclear,X-Ray, Nuclear
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Fernanda Kamila Godoy-Alvarez, and Maykel González-Torres, and David M Giraldo-Gomez, and Roberto Sánchez-Sánchez, and Mario A Pérez-Dí Az, and Manuel González-Del Carmen, and Gabriela Figueroa-González, and Octavio D Reyes-Hernández, and Javad Sharifi-Rad, and Hernán Cortés, and Marí A Luisa Del Prado-Audelo, and Gerardo Leyva-Gómez
March 2020, International journal of biological macromolecules,
Fernanda Kamila Godoy-Alvarez, and Maykel González-Torres, and David M Giraldo-Gomez, and Roberto Sánchez-Sánchez, and Mario A Pérez-Dí Az, and Manuel González-Del Carmen, and Gabriela Figueroa-González, and Octavio D Reyes-Hernández, and Javad Sharifi-Rad, and Hernán Cortés, and Marí A Luisa Del Prado-Audelo, and Gerardo Leyva-Gómez
February 2014, Carbohydrate polymers,
Fernanda Kamila Godoy-Alvarez, and Maykel González-Torres, and David M Giraldo-Gomez, and Roberto Sánchez-Sánchez, and Mario A Pérez-Dí Az, and Manuel González-Del Carmen, and Gabriela Figueroa-González, and Octavio D Reyes-Hernández, and Javad Sharifi-Rad, and Hernán Cortés, and Marí A Luisa Del Prado-Audelo, and Gerardo Leyva-Gómez
November 2006, Journal of biomedical materials research. Part B, Applied biomaterials,
Fernanda Kamila Godoy-Alvarez, and Maykel González-Torres, and David M Giraldo-Gomez, and Roberto Sánchez-Sánchez, and Mario A Pérez-Dí Az, and Manuel González-Del Carmen, and Gabriela Figueroa-González, and Octavio D Reyes-Hernández, and Javad Sharifi-Rad, and Hernán Cortés, and Marí A Luisa Del Prado-Audelo, and Gerardo Leyva-Gómez
November 2020, Carbohydrate polymers,
Fernanda Kamila Godoy-Alvarez, and Maykel González-Torres, and David M Giraldo-Gomez, and Roberto Sánchez-Sánchez, and Mario A Pérez-Dí Az, and Manuel González-Del Carmen, and Gabriela Figueroa-González, and Octavio D Reyes-Hernández, and Javad Sharifi-Rad, and Hernán Cortés, and Marí A Luisa Del Prado-Audelo, and Gerardo Leyva-Gómez
January 2017, Journal of tissue engineering,
Fernanda Kamila Godoy-Alvarez, and Maykel González-Torres, and David M Giraldo-Gomez, and Roberto Sánchez-Sánchez, and Mario A Pérez-Dí Az, and Manuel González-Del Carmen, and Gabriela Figueroa-González, and Octavio D Reyes-Hernández, and Javad Sharifi-Rad, and Hernán Cortés, and Marí A Luisa Del Prado-Audelo, and Gerardo Leyva-Gómez
May 2024, International journal of biological macromolecules,
Fernanda Kamila Godoy-Alvarez, and Maykel González-Torres, and David M Giraldo-Gomez, and Roberto Sánchez-Sánchez, and Mario A Pérez-Dí Az, and Manuel González-Del Carmen, and Gabriela Figueroa-González, and Octavio D Reyes-Hernández, and Javad Sharifi-Rad, and Hernán Cortés, and Marí A Luisa Del Prado-Audelo, and Gerardo Leyva-Gómez
March 2011, Advanced materials (Deerfield Beach, Fla.),
Fernanda Kamila Godoy-Alvarez, and Maykel González-Torres, and David M Giraldo-Gomez, and Roberto Sánchez-Sánchez, and Mario A Pérez-Dí Az, and Manuel González-Del Carmen, and Gabriela Figueroa-González, and Octavio D Reyes-Hernández, and Javad Sharifi-Rad, and Hernán Cortés, and Marí A Luisa Del Prado-Audelo, and Gerardo Leyva-Gómez
September 2021, Polymers,
Fernanda Kamila Godoy-Alvarez, and Maykel González-Torres, and David M Giraldo-Gomez, and Roberto Sánchez-Sánchez, and Mario A Pérez-Dí Az, and Manuel González-Del Carmen, and Gabriela Figueroa-González, and Octavio D Reyes-Hernández, and Javad Sharifi-Rad, and Hernán Cortés, and Marí A Luisa Del Prado-Audelo, and Gerardo Leyva-Gómez
August 2008, Journal of biomedical materials research. Part B, Applied biomaterials,
Fernanda Kamila Godoy-Alvarez, and Maykel González-Torres, and David M Giraldo-Gomez, and Roberto Sánchez-Sánchez, and Mario A Pérez-Dí Az, and Manuel González-Del Carmen, and Gabriela Figueroa-González, and Octavio D Reyes-Hernández, and Javad Sharifi-Rad, and Hernán Cortés, and Marí A Luisa Del Prado-Audelo, and Gerardo Leyva-Gómez
September 2007, Journal of materials science. Materials in medicine,
Copied contents to your clipboard!