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We have characterized three terminal deletions of the long arm of the X chromosome. Southern analysis using Xq27/q28 probes suggests that two of the deletions have breakpoints near the fragile site at Xq27.3. Flow karyotype analysis provides an estimate of 12 X 10(6) bp for the size of the deleted region. We have not detected the deletion breakpoints by pulsed-field gel electrophoresis (PFGE) using the closet DNA probes, proximal to the fragile site. The physical distance between the breakpoints and the probes may therefore be several hundred kilobases. The use of the deletion patients has allowed a preliminary physical map of Xq27/28 to be constructed. Our data suggest that the closest probes to the fragile site on the proximal side are 4D-8 (DXS98), cX55.7 (DXS105), and cX33.2 (DXS152). PFGE studies provide evidence for the physical linkage of 4D-8, cX55.7, and cX33.2. We have also found evidence for the physical linkage of F8C, G6PD, and 767 (DXS115), distal to the fragile site.
M Patterson, and
C Schwartz, and
M Bell, and
S Sauer, and
M Hofker, and
B Trask, and
G van den Engh, and
K E Davies
April 1991,
Genomics,
M Patterson, and
C Schwartz, and
M Bell, and
S Sauer, and
M Hofker, and
B Trask, and
G van den Engh, and
K E Davies
October 1991,
Proceedings of the National Academy of Sciences of the United States of America,
M Patterson, and
C Schwartz, and
M Bell, and
S Sauer, and
M Hofker, and
B Trask, and
G van den Engh, and
K E Davies
July 1993,
Genomics,
M Patterson, and
C Schwartz, and
M Bell, and
S Sauer, and
M Hofker, and
B Trask, and
G van den Engh, and
K E Davies
January 1994,
Genomics,
M Patterson, and
C Schwartz, and
M Bell, and
S Sauer, and
M Hofker, and
B Trask, and
G van den Engh, and
K E Davies
October 1991,
Genomics,
M Patterson, and
C Schwartz, and
M Bell, and
S Sauer, and
M Hofker, and
B Trask, and
G van den Engh, and
K E Davies
January 1995,
Neuropsychobiology,
M Patterson, and
C Schwartz, and
M Bell, and
S Sauer, and
M Hofker, and
B Trask, and
G van den Engh, and
K E Davies
April 2001,
Animal genetics,
M Patterson, and
C Schwartz, and
M Bell, and
S Sauer, and
M Hofker, and
B Trask, and
G van den Engh, and
K E Davies
August 1989,
Genomics,
M Patterson, and
C Schwartz, and
M Bell, and
S Sauer, and
M Hofker, and
B Trask, and
G van den Engh, and
K E Davies
March 1993,
Genomics,
M Patterson, and
C Schwartz, and
M Bell, and
S Sauer, and
M Hofker, and
B Trask, and
G van den Engh, and
K E Davies
January 2000,
Human heredity,
