-transparent.png){kind=logo}
A polygenic risk score for multiple myeloma risk prediction. 2022
Federico Canzian, and
Chiara Piredda, and
Angelica Macauda, and
Daria Zawirska, and
Niels Frost Andersen, and
Arnon Nagler, and
Jan Maciej Zaucha, and
Grzegorz Mazur, and
Charles Dumontet, and
Marzena Wątek, and
Krzysztof Jamroziak, and
Juan Sainz, and
Judit Várkonyi, and
Aleksandra Butrym, and
Katia Beider, and
Niels Abildgaard, and
Fabienne Lesueur, and
Marek Dudziński, and
Annette Juul Vangsted, and
Matteo Pelosini, and
Edyta Subocz, and
Mario Petrini, and
Gabriele Buda, and
Małgorzata Raźny, and
Federica Gemignani, and
Herlander Marques, and
Enrico Orciuolo, and
Katalin Kadar, and
Artur Jurczyszyn, and
Agnieszka Druzd-Sitek, and
Ulla Vogel, and
Vibeke Andersen, and
Rui Manuel Reis, and
Anna Suska, and
Hervé Avet-Loiseau, and
Marcin Kruszewski, and
Waldemar Tomczak, and
Marcin Rymko, and
Stephane Minvielle, and
Daniele Campa
Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. f.canzian@dkfz.de.
There is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk loci that contribute to the genetic susceptibility of MM, but have low individual penetrance. Combining the SNPs in a polygenic risk score (PRS) is a possible approach to improve their usefulness. Using 2361 MM cases and 1415 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, we computed a weighted and an unweighted PRS. We observed associations with MM risk with OR = 3.44, 95% CI 2.53-4.69, p = 3.55 × 10-15 for the highest vs. lowest quintile of the weighted score, and OR = 3.18, 95% CI 2.1 = 34-4.33, p = 1.62 × 10-13 for the highest vs. lowest quintile of the unweighted score. We found a convincing association of a PRS generated with 23 SNPs and risk of MM. Our work provides additional validation of previously discovered MM risk variants and of their combination into a PRS, which is a first step towards the use of genetics for risk stratification in the general population.
Related Publications
Federico Canzian, and
Chiara Piredda, and
Angelica Macauda, and
Daria Zawirska, and
Niels Frost Andersen, and
Arnon Nagler, and
Jan Maciej Zaucha, and
Grzegorz Mazur, and
Charles Dumontet, and
Marzena Wątek, and
Krzysztof Jamroziak, and
Juan Sainz, and
Judit Várkonyi, and
Aleksandra Butrym, and
Katia Beider, and
Niels Abildgaard, and
Fabienne Lesueur, and
Marek Dudziński, and
Annette Juul Vangsted, and
Matteo Pelosini, and
Edyta Subocz, and
Mario Petrini, and
Gabriele Buda, and
Małgorzata Raźny, and
Federica Gemignani, and
Herlander Marques, and
Enrico Orciuolo, and
Katalin Kadar, and
Artur Jurczyszyn, and
Agnieszka Druzd-Sitek, and
Ulla Vogel, and
Vibeke Andersen, and
Rui Manuel Reis, and
Anna Suska, and
Hervé Avet-Loiseau, and
Marcin Kruszewski, and
Waldemar Tomczak, and
Marcin Rymko, and
Stephane Minvielle, and
Daniele Campa
January 2021,
Frontiers in reproductive health,
Federico Canzian, and
Chiara Piredda, and
Angelica Macauda, and
Daria Zawirska, and
Niels Frost Andersen, and
Arnon Nagler, and
Jan Maciej Zaucha, and
Grzegorz Mazur, and
Charles Dumontet, and
Marzena Wątek, and
Krzysztof Jamroziak, and
Juan Sainz, and
Judit Várkonyi, and
Aleksandra Butrym, and
Katia Beider, and
Niels Abildgaard, and
Fabienne Lesueur, and
Marek Dudziński, and
Annette Juul Vangsted, and
Matteo Pelosini, and
Edyta Subocz, and
Mario Petrini, and
Gabriele Buda, and
Małgorzata Raźny, and
Federica Gemignani, and
Herlander Marques, and
Enrico Orciuolo, and
Katalin Kadar, and
Artur Jurczyszyn, and
Agnieszka Druzd-Sitek, and
Ulla Vogel, and
Vibeke Andersen, and
Rui Manuel Reis, and
Anna Suska, and
Hervé Avet-Loiseau, and
Marcin Kruszewski, and
Waldemar Tomczak, and
Marcin Rymko, and
Stephane Minvielle, and
Daniele Campa
April 2023,
JAMA internal medicine,
Federico Canzian, and
Chiara Piredda, and
Angelica Macauda, and
Daria Zawirska, and
Niels Frost Andersen, and
Arnon Nagler, and
Jan Maciej Zaucha, and
Grzegorz Mazur, and
Charles Dumontet, and
Marzena Wątek, and
Krzysztof Jamroziak, and
Juan Sainz, and
Judit Várkonyi, and
Aleksandra Butrym, and
Katia Beider, and
Niels Abildgaard, and
Fabienne Lesueur, and
Marek Dudziński, and
Annette Juul Vangsted, and
Matteo Pelosini, and
Edyta Subocz, and
Mario Petrini, and
Gabriele Buda, and
Małgorzata Raźny, and
Federica Gemignani, and
Herlander Marques, and
Enrico Orciuolo, and
Katalin Kadar, and
Artur Jurczyszyn, and
Agnieszka Druzd-Sitek, and
Ulla Vogel, and
Vibeke Andersen, and
Rui Manuel Reis, and
Anna Suska, and
Hervé Avet-Loiseau, and
Marcin Kruszewski, and
Waldemar Tomczak, and
Marcin Rymko, and
Stephane Minvielle, and
Daniele Campa
February 2024,
Communications biology,
Federico Canzian, and
Chiara Piredda, and
Angelica Macauda, and
Daria Zawirska, and
Niels Frost Andersen, and
Arnon Nagler, and
Jan Maciej Zaucha, and
Grzegorz Mazur, and
Charles Dumontet, and
Marzena Wątek, and
Krzysztof Jamroziak, and
Juan Sainz, and
Judit Várkonyi, and
Aleksandra Butrym, and
Katia Beider, and
Niels Abildgaard, and
Fabienne Lesueur, and
Marek Dudziński, and
Annette Juul Vangsted, and
Matteo Pelosini, and
Edyta Subocz, and
Mario Petrini, and
Gabriele Buda, and
Małgorzata Raźny, and
Federica Gemignani, and
Herlander Marques, and
Enrico Orciuolo, and
Katalin Kadar, and
Artur Jurczyszyn, and
Agnieszka Druzd-Sitek, and
Ulla Vogel, and
Vibeke Andersen, and
Rui Manuel Reis, and
Anna Suska, and
Hervé Avet-Loiseau, and
Marcin Kruszewski, and
Waldemar Tomczak, and
Marcin Rymko, and
Stephane Minvielle, and
Daniele Campa
October 2020,
Scientific reports,
Federico Canzian, and
Chiara Piredda, and
Angelica Macauda, and
Daria Zawirska, and
Niels Frost Andersen, and
Arnon Nagler, and
Jan Maciej Zaucha, and
Grzegorz Mazur, and
Charles Dumontet, and
Marzena Wątek, and
Krzysztof Jamroziak, and
Juan Sainz, and
Judit Várkonyi, and
Aleksandra Butrym, and
Katia Beider, and
Niels Abildgaard, and
Fabienne Lesueur, and
Marek Dudziński, and
Annette Juul Vangsted, and
Matteo Pelosini, and
Edyta Subocz, and
Mario Petrini, and
Gabriele Buda, and
Małgorzata Raźny, and
Federica Gemignani, and
Herlander Marques, and
Enrico Orciuolo, and
Katalin Kadar, and
Artur Jurczyszyn, and
Agnieszka Druzd-Sitek, and
Ulla Vogel, and
Vibeke Andersen, and
Rui Manuel Reis, and
Anna Suska, and
Hervé Avet-Loiseau, and
Marcin Kruszewski, and
Waldemar Tomczak, and
Marcin Rymko, and
Stephane Minvielle, and
Daniele Campa
February 2023,
World journal of gastrointestinal oncology,
Federico Canzian, and
Chiara Piredda, and
Angelica Macauda, and
Daria Zawirska, and
Niels Frost Andersen, and
Arnon Nagler, and
Jan Maciej Zaucha, and
Grzegorz Mazur, and
Charles Dumontet, and
Marzena Wątek, and
Krzysztof Jamroziak, and
Juan Sainz, and
Judit Várkonyi, and
Aleksandra Butrym, and
Katia Beider, and
Niels Abildgaard, and
Fabienne Lesueur, and
Marek Dudziński, and
Annette Juul Vangsted, and
Matteo Pelosini, and
Edyta Subocz, and
Mario Petrini, and
Gabriele Buda, and
Małgorzata Raźny, and
Federica Gemignani, and
Herlander Marques, and
Enrico Orciuolo, and
Katalin Kadar, and
Artur Jurczyszyn, and
Agnieszka Druzd-Sitek, and
Ulla Vogel, and
Vibeke Andersen, and
Rui Manuel Reis, and
Anna Suska, and
Hervé Avet-Loiseau, and
Marcin Kruszewski, and
Waldemar Tomczak, and
Marcin Rymko, and
Stephane Minvielle, and
Daniele Campa
July 2023,
Nature medicine,
Federico Canzian, and
Chiara Piredda, and
Angelica Macauda, and
Daria Zawirska, and
Niels Frost Andersen, and
Arnon Nagler, and
Jan Maciej Zaucha, and
Grzegorz Mazur, and
Charles Dumontet, and
Marzena Wątek, and
Krzysztof Jamroziak, and
Juan Sainz, and
Judit Várkonyi, and
Aleksandra Butrym, and
Katia Beider, and
Niels Abildgaard, and
Fabienne Lesueur, and
Marek Dudziński, and
Annette Juul Vangsted, and
Matteo Pelosini, and
Edyta Subocz, and
Mario Petrini, and
Gabriele Buda, and
Małgorzata Raźny, and
Federica Gemignani, and
Herlander Marques, and
Enrico Orciuolo, and
Katalin Kadar, and
Artur Jurczyszyn, and
Agnieszka Druzd-Sitek, and
Ulla Vogel, and
Vibeke Andersen, and
Rui Manuel Reis, and
Anna Suska, and
Hervé Avet-Loiseau, and
Marcin Kruszewski, and
Waldemar Tomczak, and
Marcin Rymko, and
Stephane Minvielle, and
Daniele Campa
January 2023,
Brain communications,
Federico Canzian, and
Chiara Piredda, and
Angelica Macauda, and
Daria Zawirska, and
Niels Frost Andersen, and
Arnon Nagler, and
Jan Maciej Zaucha, and
Grzegorz Mazur, and
Charles Dumontet, and
Marzena Wątek, and
Krzysztof Jamroziak, and
Juan Sainz, and
Judit Várkonyi, and
Aleksandra Butrym, and
Katia Beider, and
Niels Abildgaard, and
Fabienne Lesueur, and
Marek Dudziński, and
Annette Juul Vangsted, and
Matteo Pelosini, and
Edyta Subocz, and
Mario Petrini, and
Gabriele Buda, and
Małgorzata Raźny, and
Federica Gemignani, and
Herlander Marques, and
Enrico Orciuolo, and
Katalin Kadar, and
Artur Jurczyszyn, and
Agnieszka Druzd-Sitek, and
Ulla Vogel, and
Vibeke Andersen, and
Rui Manuel Reis, and
Anna Suska, and
Hervé Avet-Loiseau, and
Marcin Kruszewski, and
Waldemar Tomczak, and
Marcin Rymko, and
Stephane Minvielle, and
Daniele Campa
February 2021,
Genome medicine,
Federico Canzian, and
Chiara Piredda, and
Angelica Macauda, and
Daria Zawirska, and
Niels Frost Andersen, and
Arnon Nagler, and
Jan Maciej Zaucha, and
Grzegorz Mazur, and
Charles Dumontet, and
Marzena Wątek, and
Krzysztof Jamroziak, and
Juan Sainz, and
Judit Várkonyi, and
Aleksandra Butrym, and
Katia Beider, and
Niels Abildgaard, and
Fabienne Lesueur, and
Marek Dudziński, and
Annette Juul Vangsted, and
Matteo Pelosini, and
Edyta Subocz, and
Mario Petrini, and
Gabriele Buda, and
Małgorzata Raźny, and
Federica Gemignani, and
Herlander Marques, and
Enrico Orciuolo, and
Katalin Kadar, and
Artur Jurczyszyn, and
Agnieszka Druzd-Sitek, and
Ulla Vogel, and
Vibeke Andersen, and
Rui Manuel Reis, and
Anna Suska, and
Hervé Avet-Loiseau, and
Marcin Kruszewski, and
Waldemar Tomczak, and
Marcin Rymko, and
Stephane Minvielle, and
Daniele Campa
October 2016,
Breast cancer research and treatment,
Federico Canzian, and
Chiara Piredda, and
Angelica Macauda, and
Daria Zawirska, and
Niels Frost Andersen, and
Arnon Nagler, and
Jan Maciej Zaucha, and
Grzegorz Mazur, and
Charles Dumontet, and
Marzena Wątek, and
Krzysztof Jamroziak, and
Juan Sainz, and
Judit Várkonyi, and
Aleksandra Butrym, and
Katia Beider, and
Niels Abildgaard, and
Fabienne Lesueur, and
Marek Dudziński, and
Annette Juul Vangsted, and
Matteo Pelosini, and
Edyta Subocz, and
Mario Petrini, and
Gabriele Buda, and
Małgorzata Raźny, and
Federica Gemignani, and
Herlander Marques, and
Enrico Orciuolo, and
Katalin Kadar, and
Artur Jurczyszyn, and
Agnieszka Druzd-Sitek, and
Ulla Vogel, and
Vibeke Andersen, and
Rui Manuel Reis, and
Anna Suska, and
Hervé Avet-Loiseau, and
Marcin Kruszewski, and
Waldemar Tomczak, and
Marcin Rymko, and
Stephane Minvielle, and
Daniele Campa
August 2023,
Melanoma research,
