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We studied the effect of barbiturates on local cerebral glucose metabolism by performing positron emission scans before and after withdrawal of phenobarbital or primidone. The postwithdrawal scan showed a significant increase (mean, 37%) in seven of eight cortical regions tested. Patients who had serial scans without a drug change showed a nonsignificant tendency for metabolic rates to go down on the second scan (mean decrease, 7%). Addition or deletion of a single drug other than barbiturate did not change metabolic rates on repeat scans. The depression in cerebral glucose metabolic rate due to phenobarbital, if confirmed, may have bearing on the adverse neuropsychological effects of the drug.
W H Theodore, and
G DiChiro, and
R Margolin, and
D Fishbein, and
R J Porter, and
R A Brooks
December 1987,
No to shinkei = Brain and nerve,
W H Theodore, and
G DiChiro, and
R Margolin, and
D Fishbein, and
R J Porter, and
R A Brooks
July 1991,
Nihon rinsho. Japanese journal of clinical medicine,
W H Theodore, and
G DiChiro, and
R Margolin, and
D Fishbein, and
R J Porter, and
R A Brooks
December 1992,
The Annals of thoracic surgery,
W H Theodore, and
G DiChiro, and
R Margolin, and
D Fishbein, and
R J Porter, and
R A Brooks
January 1991,
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W H Theodore, and
G DiChiro, and
R Margolin, and
D Fishbein, and
R J Porter, and
R A Brooks
July 2007,
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W H Theodore, and
G DiChiro, and
R Margolin, and
D Fishbein, and
R J Porter, and
R A Brooks
June 1998,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
W H Theodore, and
G DiChiro, and
R Margolin, and
D Fishbein, and
R J Porter, and
R A Brooks
January 1957,
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W H Theodore, and
G DiChiro, and
R Margolin, and
D Fishbein, and
R J Porter, and
R A Brooks
January 1999,
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W H Theodore, and
G DiChiro, and
R Margolin, and
D Fishbein, and
R J Porter, and
R A Brooks
October 1982,
Science (New York, N.Y.),
W H Theodore, and
G DiChiro, and
R Margolin, and
D Fishbein, and
R J Porter, and
R A Brooks
April 1991,
The New England journal of medicine,
