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Preliminary studies related to immunotoxicologic effects of 2,5-hexanedione, the final major metabolite of n-hexane/MnBk, were carried out in rats following single or repeated exposures. Female albino rats were given either single or seven consecutive oral doses of 0.1, 0.2, or 0.5 X LD50 of 2,5-hexanedione, and a time-related kinetic study was performed using hematology, histology, cellularity, and organ weight/body weight as major parameters. Following single exposure of 2,5-hexanedione to rats, a dose-dependent thymic atrophy was evident at the end of 7 days. The atrophy was reversible when the animals were given 7 days nonexposure rest. In contrast, there was no thymic atrophy when the animals were exposed for 7 consecutive days. Significant decline in the cellular populations of various lymphoid organs was also observed in rats exposed either to single or repeated doses of 2,5-hexanedione. Results obtained in the present study indicate that 2,5-hexanedione, a known potent neurotoxic substance, adversely affects the lymphoid organs of the immune system in rats.
R K Upreti, and
K P Singh, and
A K Saxena, and
R Shanker
January 1991,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
R K Upreti, and
K P Singh, and
A K Saxena, and
R Shanker
September 1992,
Neurochemical research,
R K Upreti, and
K P Singh, and
A K Saxena, and
R Shanker
June 2010,
Human & experimental toxicology,
R K Upreti, and
K P Singh, and
A K Saxena, and
R Shanker
June 1986,
Toxicology and applied pharmacology,
R K Upreti, and
K P Singh, and
A K Saxena, and
R Shanker
June 2004,
Reproductive medicine and biology,
R K Upreti, and
K P Singh, and
A K Saxena, and
R Shanker
January 1990,
Neurotoxicology,
R K Upreti, and
K P Singh, and
A K Saxena, and
R Shanker
June 1987,
Environmental research,
R K Upreti, and
K P Singh, and
A K Saxena, and
R Shanker
March 1987,
Sangyo igaku. Japanese journal of industrial health,
R K Upreti, and
K P Singh, and
A K Saxena, and
R Shanker
February 1982,
Toxicology and applied pharmacology,
R K Upreti, and
K P Singh, and
A K Saxena, and
R Shanker
January 1999,
Nihon seirigaku zasshi. Journal of the Physiological Society of Japan,
