Biomaterial Database

Effects of PCA and DMAE on the namatode Caenorhabditis briggsae. 1978

B M Zuckerman, and K A Barrett

Concentration of 6.8 mM DMAE did not retard age pigment accumulation in Caenorhabditis briggsae. However, when the nematodes were exposed to 6.8 mM PCA + 6.8 mM DMAE combined, the accumulation of age pigment was significantly retarded. A combination of 3.4 mM DMAE + 3.4 mM PCA had no effect on age pigment. It is concluded from this study that PCA and DMAE act in concert to produce the observed effect on age pigment. In respect to this parameter neither molecule was effective alone. The results indicate that the effect of centrophenoxine on age pigment might be enhanced by retarding the hydrolysis of centrophenoxine. The accumulation of electron dense aggregates, thought to be aggregates of cross-linked molecules, was reduced by 6.8 PCA + 6.8 DMAE. It is suggested that centrophenoxine be tested for its ability to remove random, unwanted cross-linkages in higher animals.

UI	MeSH Term	Description	Entries
D008062	Lipofuscin	A naturally occurring lipid pigment with histochemical characteristics similar to ceroid. It accumulates in various normal tissues and apparently increases in quantity with age.
D009348	Nematoda	A phylum of unsegmented helminths with fundamental bilateral symmetry and secondary triradiate symmetry of the oral and esophageal structures. Many species are parasites.	Phasmidia,Secernentea,Sipunculida
D009996	Osmotic Fragility	RED BLOOD CELL sensitivity to change in OSMOTIC PRESSURE. When exposed to a hypotonic concentration of sodium in a solution, red cells take in more water, swell until the capacity of the cell membrane is exceeded, and burst.	Saline Fragility,Fragility, Osmotic,Fragility, Saline
D002504	Meclofenoxate	An ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid.	Centrophenoxine,Atsefen,Cerutil,Cetrexin,Helfergin,Meclofenoxate Hydrochloride
D003642	Deanol	An antidepressive agent that has also been used in the treatment of movement disorders. The mechanism of action is not well understood.	Dimethylaminoethanol,Astyl,Deanol Bisorcate,Demanol,Demanyl,Dimethylethanolamine,N,N-Dimethyl-2-hydroxyethylamine,N,N-Dimethylethanolamine,Tonibral,Bisorcate, Deanol,N,N Dimethyl 2 hydroxyethylamine
D004983	Ethanolamines	AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.	Aminoethanols
D006016	Glycolates	Derivatives of ACETIC ACID which contain an hydroxy group attached to the methyl carbon.	2-Hydroxyacetates,Glycolate Ethers,Hydroxyacetate Ethers,Hydroxyacetates,Hydroxyacetic Acids,2 Hydroxyacetates,Acids, Hydroxyacetic,Ethers, Glycolate,Ethers, Hydroxyacetate
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013046	Specific Gravity	The ratio of the density of a material to the density of some standard material, such as water or air, at a specified temperature.	Relative Density,Densities, Relative,Density, Relative,Gravities, Specific,Gravity, Specific,Relative Densities,Specific Gravities