| D009474 |
Neurons |
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. |
Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron |
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| D002454 |
Cell Differentiation |
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. |
Differentiation, Cell,Cell Differentiations,Differentiations, Cell |
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| D000066450 |
Mouse Embryonic Stem Cells |
PLURIPOTENT STEM CELLS derived from the BLASTOCYST INNER CELL MASS of day 3.5 mouse embryos. |
mESC,Cells, Mouse Embryonic Stem,Mouse Embryonic Stem Cell,Stem Cells, Mouse Embryonic,mESCs |
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| D000071679 |
Glycogen Synthase Kinase 3 beta |
A glycogen synthase kinase-3 type enzyme that functions in ENERGY METABOLISM; EMBRYONIC DEVELOPMENT; and NEUROGENESIS. It is also involved in PROTEIN BIOSYNTHESIS and regulates cell growth and proliferation as a component of the WNT SIGNALING PATHWAY and other signaling pathways. Certain polymorphisms in the GSK3B gene have been associated with PARKINSON DISEASE; ALZHEIMER DISEASE; and BIPOLAR DISORDER. |
GSK-3beta,GSK3B Protein,GSK3beta,GSK 3beta |
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| D000818 |
Animals |
Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. |
Animal,Metazoa,Animalia |
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| D015398 |
Signal Transduction |
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway. |
Cell Signaling,Receptor-Mediated Signal Transduction,Signal Pathways,Receptor Mediated Signal Transduction,Signal Transduction Pathways,Signal Transduction Systems,Pathway, Signal,Pathway, Signal Transduction,Pathways, Signal,Pathways, Signal Transduction,Receptor-Mediated Signal Transductions,Signal Pathway,Signal Transduction Pathway,Signal Transduction System,Signal Transduction, Receptor-Mediated,Signal Transductions,Signal Transductions, Receptor-Mediated,System, Signal Transduction,Systems, Signal Transduction,Transduction, Signal,Transductions, Signal |
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| D051076 |
Proto-Oncogene Proteins c-fyn |
Src-family kinases that associate with T-CELL ANTIGEN RECEPTOR and phosphorylate a wide variety of intracellular signaling molecules. |
Proto-Oncogene Protein p60(fyn),c-fyn Protein,fyn Proto-Oncogene Proteins,Fyn Tyrosine Kinase,Protein-Tyrosine Kinase p59(fyn),Proto-Oncogene Protein c-fyn,Proto-Oncogene Protein c-syn,Proto-Oncogene Protein p59(fyn),Proto-Oncogene Protein p72(fyn),c-fyn Proto-Oncogene Proteins,p59 c-fyn Protein,p59(fyn) Protein,p60 c-fyn Protein,p60(fyn) Protein,p72 c-fyn Protein,p72(fyn) Protein,Proteins c-fyn, Proto-Oncogene,Proto Oncogene Protein c fyn,Proto Oncogene Protein c syn,Proto Oncogene Proteins c fyn,Proto-Oncogene Proteins, c-fyn,Proto-Oncogene Proteins, fyn,Tyrosine Kinase, Fyn,c fyn Proto Oncogene Proteins,c-fyn Protein, p59,c-fyn Protein, p60,c-fyn, Proto-Oncogene Protein,c-fyn, Proto-Oncogene Proteins,c-syn, Proto-Oncogene Protein,fyn Proto Oncogene Proteins,p59 c fyn Protein,p60 c fyn Protein,p72 c fyn Protein |
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| D051360 |
Cyclin-Dependent Kinase 5 |
A serine-threonine kinase that plays important roles in CELL DIFFERENTIATION; CELL MIGRATION; and CELL DEATH of NERVE CELLS. It is closely related to other CYCLIN-DEPENDENT KINASES but does not seem to participate in CELL CYCLE regulation. |
Cdk5 Protein Kinase,Cdc2-Related Kinase PSSALRE,Cdk5 Protein,Neuronal Cdc2-Like Protein Kinase,PSSALRE Protein,Cdc2 Related Kinase PSSALRE,Cyclin Dependent Kinase 5,Neuronal Cdc2 Like Protein Kinase,PSSALRE, Cdc2-Related Kinase,Protein Kinase, Cdk5 |
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| D051379 |
Mice |
The common name for the genus Mus. |
Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus |
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| D053614 |
Janus Kinase 2 |
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS. |
JAK-2 Protein Tyrosine Kinase,JAK2 Protein Tyrosine Kinase,JAK 2 Protein Tyrosine Kinase |
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