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The biological activities of calcitonin gene-related peptide (CGRP) enzymic digest fragments, chemically modified products and beta-CGRP have been compared to that of intact alpha-CGRP on rat isolated paired atria. Tryptic and chymotryptic digests both produced inactive fragments. Acetylation of the N-terminal amino acid (Alanine) or either of Lys 24 or Lys 35, resulted in reduced, but measurable, biological activity. Destruction of the disulphide bridge between Cys 2 and Cys 7 abolished biological activity. Substitution of several amino acids, Asp 3, Val 22 and Asn 25, with Asn, Met and Ser respectively (beta-CGRP), produced a peptide with similar biological activity to alpha-CGRP.
J R Tippins, and
V Di Marzo, and
M Panico, and
H R Morris, and
I MacIntyre
December 1989,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
J R Tippins, and
V Di Marzo, and
M Panico, and
H R Morris, and
I MacIntyre
March 1995,
Nihon rinsho. Japanese journal of clinical medicine,
J R Tippins, and
V Di Marzo, and
M Panico, and
H R Morris, and
I MacIntyre
December 1999,
Nihon rinsho. Japanese journal of clinical medicine,
J R Tippins, and
V Di Marzo, and
M Panico, and
H R Morris, and
I MacIntyre
February 1994,
Presse medicale (Paris, France : 1983),
J R Tippins, and
V Di Marzo, and
M Panico, and
H R Morris, and
I MacIntyre
July 2010,
Nihon rinsho. Japanese journal of clinical medicine,
J R Tippins, and
V Di Marzo, and
M Panico, and
H R Morris, and
I MacIntyre
August 2005,
Nihon rinsho. Japanese journal of clinical medicine,
J R Tippins, and
V Di Marzo, and
M Panico, and
H R Morris, and
I MacIntyre
March 1994,
Revue du rhumatisme (Ed. francaise : 1993),
J R Tippins, and
V Di Marzo, and
M Panico, and
H R Morris, and
I MacIntyre
June 2006,
Headache,
J R Tippins, and
V Di Marzo, and
M Panico, and
H R Morris, and
I MacIntyre
March 2011,
Cephalalgia : an international journal of headache,
J R Tippins, and
V Di Marzo, and
M Panico, and
H R Morris, and
I MacIntyre
February 1989,
The American journal of physiology,
