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To test whether factor VII activation correlated with the generation of thrombin activity when plasma was exposed to a glass surface and reduced temperature, an association was sought between the changes in factor VII clotting activity (VIIc) and fibrinopeptide A concentration (an index of thrombin activity) in platelet-poor citrated plasma from 42 healthy adults. The Spearman rank correlation (rs) between responses was 0.82 (P less than 0.001). The VIIc assay response to surface/cold exposure was unaffected when thrombin was suppressed by hirudin. An assay for factor VII activity based upon its activation of tritiated factor X revealed an association between the increase in fibrinopeptide A concentration and reduction in functional factor VII concentration during activation of a subset of 22 plasma samples (rs = -0.62; P = 0.003). This loss of functional factor VII was probably due to conversion of active factor VII to its non-functional end-product by factor Xa. The results suggest that VIIc is an index of flux within the coagulation system and support the hypothesis that a high VIIc is an indicator of a hypercoagulable state.
G J Miller, and
M J Seghatchian, and
S J Walter, and
D J Howarth, and
S G Thompson, and
M P Esnouf, and
T W Meade
April 1993,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
G J Miller, and
M J Seghatchian, and
S J Walter, and
D J Howarth, and
S G Thompson, and
M P Esnouf, and
T W Meade
June 1986,
Atherosclerosis,
G J Miller, and
M J Seghatchian, and
S J Walter, and
D J Howarth, and
S G Thompson, and
M P Esnouf, and
T W Meade
February 1984,
The Journal of clinical investigation,
G J Miller, and
M J Seghatchian, and
S J Walter, and
D J Howarth, and
S G Thompson, and
M P Esnouf, and
T W Meade
December 1994,
Atherosclerosis,
G J Miller, and
M J Seghatchian, and
S J Walter, and
D J Howarth, and
S G Thompson, and
M P Esnouf, and
T W Meade
February 1994,
Arteriosclerosis and thrombosis : a journal of vascular biology,
G J Miller, and
M J Seghatchian, and
S J Walter, and
D J Howarth, and
S G Thompson, and
M P Esnouf, and
T W Meade
January 2005,
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit,
G J Miller, and
M J Seghatchian, and
S J Walter, and
D J Howarth, and
S G Thompson, and
M P Esnouf, and
T W Meade
January 1992,
Bibliotheca nutritio et dieta,
G J Miller, and
M J Seghatchian, and
S J Walter, and
D J Howarth, and
S G Thompson, and
M P Esnouf, and
T W Meade
August 1981,
Proceedings of the National Academy of Sciences of the United States of America,
G J Miller, and
M J Seghatchian, and
S J Walter, and
D J Howarth, and
S G Thompson, and
M P Esnouf, and
T W Meade
July 1989,
Atherosclerosis,
G J Miller, and
M J Seghatchian, and
S J Walter, and
D J Howarth, and
S G Thompson, and
M P Esnouf, and
T W Meade
April 2002,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
