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Nine anovulatory patients with hypothalamic-pituitary dysfunction were treated with d-Trp6-luteinizing hormone-releasing hormone, an analog with far greater gonadotropin-releasing activity than luteinizing hormone-releasing hormone. Four of eight patients, who were formerly unsuccessfully treated with clomiphene, human chorionic gonadotropin, and human menopausal gonadotropin, ovulated after treatment with the peptide alone or with peptide preceded by clomiphene, and three became pregnant. The ninth patient, who had amenorrhea and anovulation due to excessive loss of weight caused by anorexia nervosa, also ovulated after treatment with the analog. These results demonstrate the effectiveness of this potent analog for induction of ovulation and pregnancy and point favorably toward clinical applications.
C J Jaramillo, and
A Charro-Salgado, and
V Peréz-Infante, and
G L del Campo, and
J Botella-Llusiá, and
D H Coy, and
A V Schally
June 1985,
Endocrinology,
C J Jaramillo, and
A Charro-Salgado, and
V Peréz-Infante, and
G L del Campo, and
J Botella-Llusiá, and
D H Coy, and
A V Schally
September 1989,
Fertility and sterility,
C J Jaramillo, and
A Charro-Salgado, and
V Peréz-Infante, and
G L del Campo, and
J Botella-Llusiá, and
D H Coy, and
A V Schally
July 1979,
The Journal of clinical endocrinology and metabolism,
C J Jaramillo, and
A Charro-Salgado, and
V Peréz-Infante, and
G L del Campo, and
J Botella-Llusiá, and
D H Coy, and
A V Schally
December 1988,
Fertility and sterility,
C J Jaramillo, and
A Charro-Salgado, and
V Peréz-Infante, and
G L del Campo, and
J Botella-Llusiá, and
D H Coy, and
A V Schally
October 1992,
Human reproduction (Oxford, England),
C J Jaramillo, and
A Charro-Salgado, and
V Peréz-Infante, and
G L del Campo, and
J Botella-Llusiá, and
D H Coy, and
A V Schally
January 1986,
International journal of fertility,
C J Jaramillo, and
A Charro-Salgado, and
V Peréz-Infante, and
G L del Campo, and
J Botella-Llusiá, and
D H Coy, and
A V Schally
October 1996,
American journal of clinical oncology,
C J Jaramillo, and
A Charro-Salgado, and
V Peréz-Infante, and
G L del Campo, and
J Botella-Llusiá, and
D H Coy, and
A V Schally
January 1989,
Fertility and sterility,
C J Jaramillo, and
A Charro-Salgado, and
V Peréz-Infante, and
G L del Campo, and
J Botella-Llusiá, and
D H Coy, and
A V Schally
July 1975,
Obstetrics and gynecology,
C J Jaramillo, and
A Charro-Salgado, and
V Peréz-Infante, and
G L del Campo, and
J Botella-Llusiá, and
D H Coy, and
A V Schally
September 2000,
European journal of endocrinology,
