BIOMAT Database Logo BIOMAT Database Logo

Atezolizumab Treatment for Progressive Multifocal Leukoencephalopathy. 2022

Nicolas Lambert, and Solène Dauby, and Dominique Dive, and Bernard Sadzot, and Pierre Maquet

Atezolizumab successfully reinvigorated JC virus immunity in a patient in Belgium with progressive multifocal leukoencephalopathy, as demonstrated by clinical, virologic, and radiologic response to treatment. However, the treatment also resulted in immune reconstitution inflammatory syndrome and life-threatening immune-related adverse events. These conditions were treated with corticosteroids, leading to treatment resistance.

UI MeSH Term Description Entries
D007577 JC Virus A species of POLYOMAVIRUS, originally isolated from the brain of a patient with progressive multifocal leukoencephalopathy. The patient's initials J.C. gave the virus its name. Infection is not accompanied by any apparent illness but serious demyelinating disease can appear later, probably following reactivation of latent virus. Human Polyomavirus JC,JC polyomavirus,Polyomavirus, JC,John Cunningham Virus,Polyomavirus hominis 2,Polyomavirus JC, Human,Virus, John Cunningham
D007968 Leukoencephalopathy, Progressive Multifocal An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7) Encephalitis, JC Polyomavirus,Progressive Multifocal Leukoencephalopathy,JC Polyomavirus Encephalopathy,Encephalopathies, JC Polyomavirus,Encephalopathy, JC Polyomavirus,JC Polyomavirus Encephalitis,Leukoencephalopathies, Progressive Multifocal,Multifocal Leukoencephalopathies, Progressive,Multifocal Leukoencephalopathy, Progressive,Progressive Multifocal Leukoencephalopathies
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D054019 Immune Reconstitution Inflammatory Syndrome Exuberant inflammatory response towards a previously acquired or undiagnosed opportunistic infection. It is frequently seen in AIDS patients following antiretroviral treatment. Immune Reconstitution Disease,Immune Restoration Syndrome,Immune Reconstitution Syndrome,Immune Restoration Disease,Immune Reconstitution Syndromes,Immune Restoration Diseases,Reconstitution Disease, Immune,Reconstitution Syndrome, Immune,Restoration Syndrome, Immune
D061067 Antibodies, Monoclonal, Humanized Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab. Antibodies, Humanized,Humanized Antibodies

Related Publications

Nicolas Lambert, and Solène Dauby, and Dominique Dive, and Bernard Sadzot, and Pierre Maquet
Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy.
April 2019, The New England journal of medicine,
Nicolas Lambert, and Solène Dauby, and Dominique Dive, and Bernard Sadzot, and Pierre Maquet
Treatment of progressive multifocal leukoencephalopathy.
March 2013, QJM : monthly journal of the Association of Physicians,
Nicolas Lambert, and Solène Dauby, and Dominique Dive, and Bernard Sadzot, and Pierre Maquet
Treatment of progressive multifocal leukoencephalopathy.
October 2019, Journal of neurology,
Nicolas Lambert, and Solène Dauby, and Dominique Dive, and Bernard Sadzot, and Pierre Maquet
Progressive multifocal leukoencephalopathy after fingolimod treatment.
May 2018, Neurology,
Nicolas Lambert, and Solène Dauby, and Dominique Dive, and Bernard Sadzot, and Pierre Maquet
Progressive multifocal leukoencephalopathy.
June 2002, Neurology,
Nicolas Lambert, and Solène Dauby, and Dominique Dive, and Bernard Sadzot, and Pierre Maquet
Progressive multifocal leukoencephalopathy.
October 1961, The New England journal of medicine,
Nicolas Lambert, and Solène Dauby, and Dominique Dive, and Bernard Sadzot, and Pierre Maquet
Progressive multifocal leukoencephalopathy.
January 1981, Clinical and experimental neurology,
Nicolas Lambert, and Solène Dauby, and Dominique Dive, and Bernard Sadzot, and Pierre Maquet
[Progressive multifocal leukoencephalopathy].
January 1972, Neuropatologia polska,
Nicolas Lambert, and Solène Dauby, and Dominique Dive, and Bernard Sadzot, and Pierre Maquet
Progressive multifocal leukoencephalopathy.
May 1976, Radiology,
Nicolas Lambert, and Solène Dauby, and Dominique Dive, and Bernard Sadzot, and Pierre Maquet
Progressive multifocal leukoencephalopathy.
May 1972, The New England journal of medicine,
Copied contents to your clipboard!