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Bone turnover was determined in 125 patients with rheumatoid arthritis (RA). Bone Gla protein (BGP) and alkaline phosphatase (AP) were used as markers of bone formation. Fasting urinary calcium relative to creatinine (FU Ca/Cr) and fasting urinary hydroxyproline relative to creatinine (FU Hpr/Cr) were used as markers of bone resorption. These variables were compared to the values of two groups of normal controls in order to elucidate the pathophysiology of the osteopenia occurring in patients with RA. When the patients were divided into groups according to treatment (gold salts, penicillamine, or glucocorticoids), serum AP was highly significantly increased in all three groups, whereas serum BGP was below the normal mean. FU Ca/Cr and FU Hpr/Cr were moderately decreased in the groups treated with gold salts or penicillamine, but increased in the glucocorticoid-treated group. When divided according to sex and menopausal state and glucocorticoid treatment versus non-glucocorticoid treatment, there was a balance between bone formation and bone resorption parameters in all groups, except glucocorticoid-treated men and premenopausal women who had increased values of bone resorption parameters.
O S Als, and
B J Riis, and
A Gotfredsen, and
C Christiansen, and
L J Deftos
June 1984,
Clinical rheumatology,
O S Als, and
B J Riis, and
A Gotfredsen, and
C Christiansen, and
L J Deftos
August 1991,
The Journal of rheumatology,
O S Als, and
B J Riis, and
A Gotfredsen, and
C Christiansen, and
L J Deftos
August 2009,
Clinical calcium,
O S Als, and
B J Riis, and
A Gotfredsen, and
C Christiansen, and
L J Deftos
January 2003,
Clinical and experimental rheumatology,
O S Als, and
B J Riis, and
A Gotfredsen, and
C Christiansen, and
L J Deftos
September 1999,
Bone,
O S Als, and
B J Riis, and
A Gotfredsen, and
C Christiansen, and
L J Deftos
January 2004,
Internal medicine journal,
O S Als, and
B J Riis, and
A Gotfredsen, and
C Christiansen, and
L J Deftos
August 2009,
Clinical calcium,
O S Als, and
B J Riis, and
A Gotfredsen, and
C Christiansen, and
L J Deftos
February 2001,
Rheumatic diseases clinics of North America,
O S Als, and
B J Riis, and
A Gotfredsen, and
C Christiansen, and
L J Deftos
September 1985,
Annals of the rheumatic diseases,
O S Als, and
B J Riis, and
A Gotfredsen, and
C Christiansen, and
L J Deftos
May 1999,
British journal of obstetrics and gynaecology,
