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The level of urinary Meg-CSF activity in patients with various thrombopoietic disorders was studied. Five out of eight patients with idiopathic thrombocytopenic purpura had megakaryocytic hyperplasia in the marrow and increased Meg-CSF activity in the urine. Urinary Meg-CSF activity in patients with polycythaemia vera and essential thrombocythaemia was normal. There was a significant inverse correlation between urinary Meg-CSF activity and peripheral blood platelet count but not bone marrow megakaryocyte mass. There was a significant increase of urinary Meg-CSF activity during the period of thrombocytopenia after chemotherapy in patients with acute leukaemia who were in complete remission. The timing of maximal Meg-CSF levels corresponded to the nadirs of platelet counts. These results support the concept that Meg-CSF may play a significant role in the regulation of megakaryopoiesis and/or thrombopoiesis in vivo.
M Kawakita, and
S Yamamoto, and
N Asou, and
M Ishii, and
M Sakaguchi, and
K Takatsuki
July 1986,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
M Kawakita, and
S Yamamoto, and
N Asou, and
M Ishii, and
M Sakaguchi, and
K Takatsuki
January 1986,
Progress in clinical and biological research,
M Kawakita, and
S Yamamoto, and
N Asou, and
M Ishii, and
M Sakaguchi, and
K Takatsuki
January 1989,
Experimental cell biology,
M Kawakita, and
S Yamamoto, and
N Asou, and
M Ishii, and
M Sakaguchi, and
K Takatsuki
October 1984,
Experimental hematology,
M Kawakita, and
S Yamamoto, and
N Asou, and
M Ishii, and
M Sakaguchi, and
K Takatsuki
September 1989,
Hematology/oncology clinics of North America,
M Kawakita, and
S Yamamoto, and
N Asou, and
M Ishii, and
M Sakaguchi, and
K Takatsuki
June 1987,
The Journal of clinical investigation,
M Kawakita, and
S Yamamoto, and
N Asou, and
M Ishii, and
M Sakaguchi, and
K Takatsuki
August 1990,
Experimental hematology,
M Kawakita, and
S Yamamoto, and
N Asou, and
M Ishii, and
M Sakaguchi, and
K Takatsuki
January 1990,
International journal of cell cloning,
M Kawakita, and
S Yamamoto, and
N Asou, and
M Ishii, and
M Sakaguchi, and
K Takatsuki
June 1986,
The Journal of clinical investigation,
M Kawakita, and
S Yamamoto, and
N Asou, and
M Ishii, and
M Sakaguchi, and
K Takatsuki
January 1983,
Journal of cellular biochemistry,
