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Depression of lymphocyte proliferative response occurs after trauma and hemorrhage. Because abnormalities in production or utilization of interleukin 2 (IL-2) can result in depression of mitogen-induced lymphocyte proliferation, we investigated the effects of unanesthetized hemorrhage on the generation of IL-2 by rat peripheral blood lymphocytes and the response of these cells to exogenous IL-2. Two hours after loss of 30% of total blood volume, IL-2 production was reduced by greater than 90%. Return to normal levels of IL-2 generation occurred by 48 hr after hemorrhage. Addition of purified rat IL-2 to cultures of phytohemagglutin-stimulated peripheral blood lymphocytes obtained from normal animals resulted in suppression of the proliferative response. Exogenous IL-2 produced a similar degree of suppression in the proliferation of cells obtained from hemorrhaged animals. These results show a profound hemorrhage-induced suppression of IL-2 generation, but no benefits of exogenous IL-2 in improving the depressed lymphocyte proliferative response that exists after hemorrhage.
E Abraham, and
R J Lee, and
Y H Chang
October 1986,
Critical care medicine,
E Abraham, and
R J Lee, and
Y H Chang
December 1993,
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E Abraham, and
R J Lee, and
Y H Chang
September 1980,
Cellular immunology,
E Abraham, and
R J Lee, and
Y H Chang
January 1987,
Clinical and experimental immunology,
E Abraham, and
R J Lee, and
Y H Chang
March 1993,
The Journal of allergy and clinical immunology,
E Abraham, and
R J Lee, and
Y H Chang
January 1985,
Circulatory shock,
E Abraham, and
R J Lee, and
Y H Chang
September 1983,
Journal of immunology (Baltimore, Md. : 1950),
E Abraham, and
R J Lee, and
Y H Chang
January 1993,
DNA and cell biology,
E Abraham, and
R J Lee, and
Y H Chang
April 1985,
Journal of immunology (Baltimore, Md. : 1950),
E Abraham, and
R J Lee, and
Y H Chang
December 1991,
Lymphokine and cytokine research,
