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[Ultrasound biomicroscopic differences between fellow eyes of acute angle-closure glaucoma and chronic angle-closure glaucoma]. 2021

Z Q Liang, and S Q You, and Y Zhang, and K Y Yang, and Z Q Ren, and X R Hou, and Y Liang, and H J Wu
Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing 100044, China.

Objective: To compare the structural differences of the anterior segment between fellow eyes of acute angle-closure glaucoma (AACG) and the eyes of chronic angle-closure glaucoma (CACG) with milder glaucomatous damage. Methods: In this case-control study, patients with AACG (41 eyes) and CACG (46 eyes) without prior treatment in the glaucoma clinic of Peking University People's Hospital from September 2016 to October 2018 were enrolled. Ultrasound biomicroscopy was performed under dark condition. Parameters were measured on images including lens vault (LV), anterior chamber depth (ACD), iris thickness (IT750 and IT2000), angle-opening distance (AOD500 and AOD750), and trabecular iris angle (TIA500 and TIA750). The independent t-test was used to compare the continuous variables of the fellow eyes of AACG patients and the eyes of CACG patients with milder glaucomatous damage. After adjusting for age and gender, univariate and multivariate logistic regression analyses were performed to explore the most important parameters that may distinguish AACG from CACG. Results: The mean age of AACG patients was (65±10) years old and the age of CACG patients was (67±12) years old (P>0.05). The ACD [(1.79±0.25) mm vs. (1.99±0.34) mm], IT750 [(0.39±0.07) mm vs. (0.43±0.05) mm], AOD500 [(0.12±0.06) mm vs. (0.15±0.07) mm], TIA500 (10.91°±5.23° vs. 13.93°±6.33°), and TIA750 (9.33°±5.02° vs. 13.93°±6.82°) were less and the LV [(0.99±0.44) mm vs. (0.72±0.30) mm] was greater in the fellow eyes of AACG as compared to the eyes of CACG with milder glaucomatous damage (all P<0.05). In the forward multivariate logistic regression analysis, every 1-degree decrease in TIA750 (odds ratio=0.872, 95%CI: 0.794 to 0.958, P<0.01) and every 1-mm increase in LV (odds ratio=14.138, 95%CI: 2.348 to 85.130, P<0.01) were significantly associated with AACG. Conclusions: Compared with the eyes of CACG with milder glaucomatous damage, fellow eyes of AACG have thinner peripheral iris thickness, narrower angle width, shallower ACD, and greater LV. LV and TIA750 may play important roles in distinguishing eyes predisposed to AACG or CACG. (Chin J Ophthalmol, 2021, 57: 672-678).

UI MeSH Term Description Entries
D007498 Iris The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000869 Anterior Eye Segment The front third of the eyeball that includes the structures between the front surface of the cornea and the front of the VITREOUS BODY. Anterior Eye Segments,Eye Segment, Anterior,Eye Segments, Anterior,Segment, Anterior Eye,Segments, Anterior Eye
D015812 Glaucoma, Angle-Closure A form of glaucoma in which the intraocular pressure increases because the angle of the anterior chamber is blocked and the aqueous humor cannot drain from the anterior chamber. Glaucoma, Closed-Angle,Glaucoma, Angle Closure,Glaucoma, Narrow-Angle,Glaucoma, Uncompensated,Glaucoma, Uncompensative,Angle Closure Glaucoma,Angle Closure Glaucomas,Angle-Closure Glaucoma,Angle-Closure Glaucomas,Closed-Angle Glaucoma,Closed-Angle Glaucomas,Glaucoma, Closed Angle,Glaucoma, Narrow Angle,Glaucomas, Angle Closure,Glaucomas, Angle-Closure,Glaucomas, Closed-Angle,Glaucomas, Narrow-Angle,Glaucomas, Uncompensated,Glaucomas, Uncompensative,Narrow-Angle Glaucoma,Narrow-Angle Glaucomas,Uncompensated Glaucoma,Uncompensated Glaucomas,Uncompensative Glaucoma,Uncompensative Glaucomas
D016022 Case-Control Studies Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time. Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control
D033401 Microscopy, Acoustic A scientific tool based on ULTRASONOGRAPHY and used not only for the observation of microstructure in metalwork but also in living tissue. In biomedical application, the acoustic propagation speed in normal and abnormal tissues can be quantified to distinguish their tissue elasticity and other properties. Acoustic Microscopy,Microscopy, Scanning Acoustic,Scanning Acoustic Microscopy,Ultrasonic Biomicroscopy,Ultrasonographic Biomicroscopy,Ultrasound Biomicroscopy,Acoustic Microscopies,Acoustic Microscopies, Scanning,Acoustic Microscopy, Scanning,Biomicroscopies, Ultrasonic,Biomicroscopies, Ultrasonographic,Biomicroscopies, Ultrasound,Biomicroscopy, Ultrasonic,Biomicroscopy, Ultrasonographic,Biomicroscopy, Ultrasound,Microscopies, Acoustic,Microscopies, Scanning Acoustic,Scanning Acoustic Microscopies,Ultrasonic Biomicroscopies,Ultrasonographic Biomicroscopies,Ultrasound Biomicroscopies

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