Biomaterial Database

Hair Growth-Promoting Effect of Resveratrol in Mice, Human Hair Follicles and Dermal Papilla Cells. 2021

Yuting Zhang, and Chunya Ni, and Yan Huang, and Yulong Tang, and Kai Yang, and Xiangguang Shi, and Yue Zhang, and Zheng Li, and Ji'an Wang, and Yifei Zhu, and Haiyang Li, and Yanyun Ma, and Jinran Lin, and Jiucun Wang, and Qingmei Liu, and Wenyu Wu

State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.

BACKGROUND Oxidative damage has been found in various types of hair loss. As a polyphenolic phytoalexin, resveratrol (RSV) is known as an antioxidant, anti-inflammatory and anti-apoptotic agent. OBJECTIVE Thus, we aim to examine the effects of RSV on hair growth. METHODS In vivo C57BL/6 mice were used to evaluate the effects of RSV on hair cycle, hair length, skin thickness, hair follicle diameter, hair cycle score and the percentage of hair cycle stage. Then hair shaft length and hair cycle were evaluated by human hair follicles (HFs) ex vivo. The proliferative activities of human dermal papilla cells (hDPCs) cultured in vitro with RSV were assessed using RTCA. The ability of RSV to protect hDPCs against H2O2-induced oxidative damage is examined by a ROS assay kit. RESULTS Topical application of RSV significantly promoted hair growth and stimulated the transition of hair cycle from telogen into the anagen phase on shaved C57BL/6 mice. Ex vivo experiments showed that RSV increased the hair shaft length of HFs and delayed the entry into catagen. In vitro experiments indicated that RSV proliferated hDPCs and prevented hDPCs from oxidative damage caused by H2O2. CONCLUSIONS RSV can promote hair growth and may be a potential candidate for the treatment of hair loss.