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The influence of technical factor variations on serum bactericidal and serum inhibitory titers was studied by using Staphylococcus aureus clinical isolates versus oxacillin-spiked human serum. Parallel tests, both with and without the use of beta-lactamase in count plates to inactivate oxacillin carryover, were performed with a conventional macrodilution approach, a carefully controlled macrodilution procedure, and a standard microdilution method. Careful control of technical factor variations diminished the incidence of low serum bactericidal titers and decreased the dispersion of results, a finding corollary to the known influence of technical factor variations on the measurement of MBCs. The incorporation of beta-lactamase into count plates resulted in a shift of serum bactericidal titers to lower values. The microdilution method appeared to be least influenced by technical variations and, with the addition of beta-lactamase to count plates, provided the best results.
B F Woolfrey, and
R T Lally, and
K R Tait
January 1970,
Journal of surgical oncology,
B F Woolfrey, and
R T Lally, and
K R Tait
August 1997,
Diagnostic microbiology and infectious disease,
B F Woolfrey, and
R T Lally, and
K R Tait
December 1975,
The Journal of laboratory and clinical medicine,
B F Woolfrey, and
R T Lally, and
K R Tait
February 1986,
European journal of clinical microbiology,
B F Woolfrey, and
R T Lally, and
K R Tait
February 1986,
European journal of clinical microbiology,
B F Woolfrey, and
R T Lally, and
K R Tait
December 1953,
California medicine,
B F Woolfrey, and
R T Lally, and
K R Tait
January 1996,
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B F Woolfrey, and
R T Lally, and
K R Tait
January 1978,
Avian diseases,
B F Woolfrey, and
R T Lally, and
K R Tait
February 1982,
Immunology letters,
B F Woolfrey, and
R T Lally, and
K R Tait
June 1985,
Infection and immunity,
