Biomaterial Database

Metabolism of 3-nitrophenol by the frog Rana temporaria. 1986

G Frank, and J Beyer

Frogs injected with 3-nitrophenol excreted 85-93% of the administered dose within 17 h; 70-90% dose was metabolized. Metabolites identified comprise 3-nitrophenyl glucuronide (57% dose), 3-nitrophenyl sulphate (24% dose), and 3-acetamidophenyl sulphate (2% dose). Traces of the following metabolites were found: 3-acetamidophenyl glucuronide, 3-acetamidophenol, 4-nitrocatechol, nitroquinol, 4-nitrocatechol sulphate and nitroquinol sulphate.

UI	MeSH Term	Description	Entries
D009596	Nitrophenols	PHENOLS carrying nitro group substituents.	Nitrophenol
D011896	Rana temporaria	A species of the family Ranidae occurring in a wide variety of habitats from within the Arctic Circle to South Africa, Australia, etc.	European Common Frog,Frog, Common European,Common European Frog,Common Frog, European,European Frog, Common,Frog, European Common
D002851	Chromatography, High Pressure Liquid	Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.	Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D006868	Hydrolysis	The process of cleaving a chemical compound by the addition of a molecule of water.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001711	Biotransformation	The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.