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This paper presents clinical, immunological and post-mortem findings in three family members (husband, wife and daughter) who all died in 1976 after having had chronic and recurrent opportunistic infections for many years. In all of them a progressive, presumably acquired T-lymphocyte defect associated with B-lymphocyte dysfunction had been diagnosed several years before death. The clinical and immunological findings are compatible with those seen in acquired immunodeficiency syndrome (AIDS) caused by HTLV-III/LAV infection, but examinations of stored blood samples from the three patients were negative with regard to the presence of HTLV-III/LAV antibodies. This immunodeficiency may therefore have been caused by an infectious agent of unknown nature. The most remarkable finding on post-mortem examination was the presence of a granulomatous encephalomyelitis with multinucleated giant cells in the husband and his wife. In addition, the wife's CNS revealed scattered microglial nodules. No infectious agents could be demonstrated, and the etiology of this peculiar CNS affection therefore remains obscure.
C F Lindboe, and
S S Frøland, and
K W Wefring, and
P J Linnestad, and
T Bøhmer, and
A Foerster, and
A C Løken
January 1986,
Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie,
C F Lindboe, and
S S Frøland, and
K W Wefring, and
P J Linnestad, and
T Bøhmer, and
A Foerster, and
A C Løken
January 1986,
Der Pathologe,
C F Lindboe, and
S S Frøland, and
K W Wefring, and
P J Linnestad, and
T Bøhmer, and
A Foerster, and
A C Løken
November 1987,
Acta pathologica japonica,
C F Lindboe, and
S S Frøland, and
K W Wefring, and
P J Linnestad, and
T Bøhmer, and
A Foerster, and
A C Løken
May 1988,
Archives of pathology & laboratory medicine,
C F Lindboe, and
S S Frøland, and
K W Wefring, and
P J Linnestad, and
T Bøhmer, and
A Foerster, and
A C Løken
July 1985,
Gastroenterology,
C F Lindboe, and
S S Frøland, and
K W Wefring, and
P J Linnestad, and
T Bøhmer, and
A Foerster, and
A C Løken
August 2006,
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi,
C F Lindboe, and
S S Frøland, and
K W Wefring, and
P J Linnestad, and
T Bøhmer, and
A Foerster, and
A C Løken
January 1985,
Vutreshni bolesti,
C F Lindboe, and
S S Frøland, and
K W Wefring, and
P J Linnestad, and
T Bøhmer, and
A Foerster, and
A C Løken
February 1993,
AIDS (London, England),
C F Lindboe, and
S S Frøland, and
K W Wefring, and
P J Linnestad, and
T Bøhmer, and
A Foerster, and
A C Løken
April 1983,
Journal of clinical immunology,
C F Lindboe, and
S S Frøland, and
K W Wefring, and
P J Linnestad, and
T Bøhmer, and
A Foerster, and
A C Løken
February 1994,
Archives of psychiatric nursing,
