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Administration of antimineralocorticoid spironolactone (SPL) to rats results in modest destruction of hepatic cytochrome P-450 with parallel loss of heme. This process is accentuated by pretreatment with dexamethasone (DEX), an inducer of cytochrome P-450p and is associated with marked functional loss of cytochrome P-450p-dependent hydroxylases. Cytochrome P-450 destruction may be replicated in vitro when microsomes from DEX-pretreated rats are incubated with SPL and NADPH and is impaired when these rats are given triacetyloleandomycin, an inhibitor of cytochrome P-450p. In vitro SPL-mediated cytochrome P-450 destruction is accompanied by a loss of heme, which appears to be converted to reactive intermediates which covalently bind to microsomes or are converted to polar metabolites.
C Decker, and
K Sugiyama, and
M Underwood, and
M A Correia
May 1980,
Biochemical and biophysical research communications,
C Decker, and
K Sugiyama, and
M Underwood, and
M A Correia
June 1980,
The Journal of biological chemistry,
C Decker, and
K Sugiyama, and
M Underwood, and
M A Correia
May 1980,
Molecular pharmacology,
C Decker, and
K Sugiyama, and
M Underwood, and
M A Correia
March 1986,
The Journal of pharmacology and experimental therapeutics,
C Decker, and
K Sugiyama, and
M Underwood, and
M A Correia
May 1981,
Biochemical pharmacology,
C Decker, and
K Sugiyama, and
M Underwood, and
M A Correia
January 1994,
Drug metabolism and disposition: the biological fate of chemicals,
C Decker, and
K Sugiyama, and
M Underwood, and
M A Correia
January 1981,
Essays in biochemistry,
C Decker, and
K Sugiyama, and
M Underwood, and
M A Correia
January 1986,
Postepy biochemii,
C Decker, and
K Sugiyama, and
M Underwood, and
M A Correia
July 1982,
Biochemical and biophysical research communications,
C Decker, and
K Sugiyama, and
M Underwood, and
M A Correia
January 1980,
Biofizika,
